Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50017396
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 400nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 700nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181674(6'-methoxy-6-oxo-1,6-dihydro-[3,3']bipyridinyl-5-c...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 3.60E+3nMAssay Description:Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181671(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181679(5-(2-methyl-benzothiazol-5-yl)-2-oxo-1,2-dihydro-p...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 3.80E+3nMAssay Description:Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibitory activity against Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181682(2-oxo-5-quinoxalin-6-yl-1,2-dihydro-pyridine-3-car...)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 6.50E+3nMAssay Description:Antiproliferative activity against murine BaF3 cell line expressing NPM-ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory activity against IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181682(2-oxo-5-quinoxalin-6-yl-1,2-dihydro-pyridine-3-car...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 7.50E+3nMAssay Description:Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181673(5-(3,4,5-trimethoxyphenyl)-2-oxo-1,2-dihydro-pyrid...)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 9.40E+3nMAssay Description:Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 9.50E+3nMAssay Description:Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 1.12E+4nMAssay Description:Antiproliferative activity against human NPM-ALK positive anaplastic large cell lymphoma karpas299 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 1.29E+4nMAssay Description:Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 1.37E+4nMAssay Description:Antiproliferative activity against murine BaF3 cell line expressing NPM-ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181683(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181674(6'-methoxy-6-oxo-1,6-dihydro-[3,3']bipyridinyl-5-c...)
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181676(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 1.46E+4nMAssay Description:Antiproliferative activity against human BCR-ABL positive chronic myeloid leukemia K562 cell lineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory activity against IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181679(5-(2-methyl-benzothiazol-5-yl)-2-oxo-1,2-dihydro-p...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 1.74E+4nMAssay Description:Antiproliferative activity against murine BaF3 cell line expressing NPM-ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181680(6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carboxylic a...)
Affinity DataIC50: 1.95E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against Flt3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181670(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181675(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against IGF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181672(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory activity against AblMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181677(5-benzo[1,3]dioxol-5-yl-2-methoxy-N-[4-(4-methyl-p...)
Affinity DataIC50: 2.03E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181669(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 2.50E+4nMAssay Description:Antiproliferative activity against murine BaF3 cell line expressing NPM-ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181678(5-benzo[1,3]dioxol-5-yl-2-chloro-N-[4-(4-methyl-pi...)
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181678(5-benzo[1,3]dioxol-5-yl-2-chloro-N-[4-(4-methyl-pi...)
Affinity DataIC50: 2.73E+4nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181671(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 3.25E+4nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181673(5-(3,4,5-trimethoxyphenyl)-2-oxo-1,2-dihydro-pyrid...)
Affinity DataIC50: 3.35E+4nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181681(5-benzo[1,3]dioxol-5-yl-1-methyl-2-oxo-1,2-dihydro...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity against ALKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181680(6-oxo-1,6-dihydro-[3,4']bipyridinyl-5-carboxylic a...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Chembridge Research Laboratories and Chembridge

Curated by ChEMBL
LigandPNGBDBM50181676(5-benzo[1,3]dioxol-5-yl-2-oxo-1,2-dihydro-pyridine...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity against IRKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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