Compile Data Set for Download or QSAR
Report error Found 7 Enz. Inhib. hit(s) with all data for entry = 50039278
TargetGlycogen synthase kinase-3 beta(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50325986(3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of GSK-3 beta in mouse D3 cells assessed as induction of neuron specific marker neurofilament-M by immunofluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50325986(3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-...)
Affinity DataKd:  126nMAssay Description:Inhibition of GSK-3 beta in mouse D3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50325986(3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of GSK-3 beta in mouse D3 cells assessed as induction of neuron specific marker beta3-tubulin by immunofluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM22449(N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-1,3-oxazol-2-yl...)
Affinity DataEC50:  2.90E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of alpha-tubulin acetylation by fluorescence microscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50325986(3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of GSK-3 beta in mouse D3 cells assessed as induction of neuron specific marker neurofilament-M by immunofluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50167161((E)-3-{3-[Cyclohexanecarbonyl-(4'-dimethylamino-bi...)
Affinity DataEC50:  25nMAssay Description:Agonist activity at FXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Mouse)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50325986(3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-...)
Affinity DataIC50: 30nMAssay Description:Binding affinity to GSK-3 beta in mouse D3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed