Compile Data Set for Download or QSAR
Report error Found 25 Enz. Inhib. hit(s) with all data for entry = 1439
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11453(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50: 120nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
LigandPNGBDBM11448(4-{[5-(cyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyrimi...)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Vernalis (R&D)

LigandPNGBDBM11448(4-{[5-(cyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyrimi...)
Affinity DataIC50: 190nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11454(5-N-(4-aminocyclohexyl)-7-N-(4-methanesulfonylphen...)
Affinity DataIC50: 250nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11455(5-N-(4-aminocyclohexyl)-7-N-[4-(benzenesulfonyl)ph...)
Affinity DataIC50: 260nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11452(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50: 270nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11448(4-{[5-(cyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyrimi...)
Affinity DataIC50: 350nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11451(4-{[5-(diethylamino)-[1,2,4]triazolo[1,5-a]pyrimid...)
Affinity DataIC50: 400nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11449(4-{[5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a]pyri...)
Affinity DataIC50: 730nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Rat)
Vernalis (R&D)

LigandPNGBDBM11452(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50: 780nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Vernalis (R&D)

LigandPNGBDBM11449(4-{[5-(cyclohexylamino)-[1,2,4]triazolo[1,5-a]pyri...)
Affinity DataIC50: 970nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11444(5-(3-bromophenyl)-N-(pyridin-4-ylmethyl)pyrazolo[1...)
Affinity DataIC50: 1.80E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
LigandPNGBDBM11451(4-{[5-(diethylamino)-[1,2,4]triazolo[1,5-a]pyrimid...)
Affinity DataIC50: 3.40E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
LigandPNGBDBM11455(5-N-(4-aminocyclohexyl)-7-N-[4-(benzenesulfonyl)ph...)
Affinity DataIC50: 4.30E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
LigandPNGBDBM11453(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50: 5.60E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11450(4-({5-[(4-hydroxycyclohexyl)amino]-[1,2,4]triazolo...)
Affinity DataIC50: 7.40E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
LigandPNGBDBM11457(5-(3-bromophenyl)-N-(pyridin-4-ylmethyl)-1H-1,3,4,...)
Affinity DataIC50: 8.80E+3nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Vernalis (R&D)

LigandPNGBDBM11451(4-{[5-(diethylamino)-[1,2,4]triazolo[1,5-a]pyrimid...)
Affinity DataIC50: 1.10E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11447(4-{[5-(cyclohexylmethoxy)-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: 1.10E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM11454(5-N-(4-aminocyclohexyl)-7-N-(4-methanesulfonylphen...)
Affinity DataIC50: 1.60E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Vernalis (R&D)

LigandPNGBDBM11453(4-({5-[(4-aminocyclohexyl)amino]-[1,2,4]triazolo[1...)
Affinity DataIC50: 2.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11457(5-(3-bromophenyl)-N-(pyridin-4-ylmethyl)-1H-1,3,4,...)
Affinity DataIC50: 2.60E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK enzyme was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Vernalis (R&D)

LigandPNGBDBM11447(4-{[5-(cyclohexylmethoxy)-[1,2,4]triazolo[1,5-a]py...)
Affinity DataIC50: 2.90E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Vernalis (R&D)

LigandPNGBDBM11454(5-N-(4-aminocyclohexyl)-7-N-(4-methanesulfonylphen...)
Affinity DataIC50: 4.30E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Vernalis (R&D)

LigandPNGBDBM11455(5-N-(4-aminocyclohexyl)-7-N-[4-(benzenesulfonyl)ph...)
Affinity DataIC50: 5.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed