Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 1022
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8117(N-{(1S,2R,4S)-1-(3-bromobenzyl)-4-[(4-fluorophenyl...)
Affinity DataKi:  45nM ΔG°:  -41.9kJ/mole IC50: 85nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2006
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8123(N-[(2S,3R,5S)-1-(3-bromophenyl)-3-hydroxy-7-methyl...)
Affinity DataKi:  370nM ΔG°:  -36.7kJ/mole IC50: 530nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2006
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8124(N-((1S,2R,4S)-1-(3-bromobenzyl)-4-{[4-(dimethylami...)
Affinity DataKi:  540nM ΔG°:  -35.8kJ/mole IC50: 790nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2006
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8118(N-[(2R,3S,5R)-1-(3-bromophenyl)-5-[(4-fluorobenzen...)
Affinity DataKi:  1.40E+3nM ΔG°:  -33.4kJ/mole IC50: 2.00E+3nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2006
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8121((2R)-N-{(1S,2R,4S)-1-(3-bromobenzyl)-6-(2,4-dichlo...)
Affinity DataKi:  2.90E+3nM ΔG°:  -31.6kJ/mole IC50: 4.20E+3nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2006
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8120(2-bromo-N-{(1S,2R,4S)-1-(3-bromobenzyl)-6-(2,4-dic...)
Affinity DataKi:  3.10E+3nM ΔG°:  -31.4kJ/mole IC50: 4.50E+3nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2006
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8119(N-[(2S,3R,5S)-1-(3-bromophenyl)-7-(2,4-dichlorophe...)
Affinity DataKi:  7.00E+3nM ΔG°:  -29.4kJ/mole IC50: 1.00E+4nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2006
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8116(N-{(1S,2R,4S)-1-(3-bromobenzyl)-2-hydroxy-4-[(3-me...)
Affinity DataKi: >4.00E+4nM ΔG°: >-25.1kJ/mole IC50: 4.00E+4nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2006
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Philipps-Universitat Marburg

LigandPNGBDBM8122((2R)-N-{(1R,2S,4R)-1-(3-bromobenzyl)-6-(2,4-dichlo...)
Affinity DataKi: >4.00E+4nM ΔG°: >-25.1kJ/mole IC50: 4.00E+4nMpH: 5.5 T: 2°CAssay Description:The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2006
Entry Details Article
PubMed