Compile Data Set for Download or QSAR
Report error Found 67 Enz. Inhib. hit(s) with all data for entry = 50016917
TargetProto-oncogene tyrosine-protein kinase LCK(Mouse)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataEC50:  78nMAssay Description:Inhibition of TCR stimulated IL2 production in mice administered orallyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175210(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175200(N-(4-(4-amino-1-(1-(1-methylpiperidin-4-yl)piperid...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175200(N-(4-(4-amino-1-(1-(1-methylpiperidin-4-yl)piperid...)
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175209(N-(4-(4-amino-1-(1-methylpiperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175199(N-(4-(1-(1-(1-acetylpiperidin-4-yl)piperidin-4-yl)...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175197(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 35nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175198(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175205(N-(4-(4-amino-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 50nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175210(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 54nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175201(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 54nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175195(N-(4-(1-(1-(1-acetylpiperidin-4-yl)piperidin-4-yl)...)
Affinity DataIC50: 74nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175205(N-(4-(4-amino-1-(piperidin-4-yl)-1H-pyrazolo[3,4-d...)
Affinity DataIC50: 80nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 80nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175199(N-(4-(1-(1-(1-acetylpiperidin-4-yl)piperidin-4-yl)...)
Affinity DataIC50: 93nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175198(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 102nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175209(N-(4-(4-amino-1-(1-methylpiperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50: 106nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175197(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 106nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175207(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 107nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175207(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 107nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 147nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175201(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 318nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175211(N-(4-(4-amino-1-(1-benzylpiperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50: 341nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175211(N-(4-(4-amino-1-(1-benzylpiperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50: 540nMAssay Description:Inhibitory activity against anti-CD3 mAb-induced IL2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175200(N-(4-(4-amino-1-(1-(1-methylpiperidin-4-yl)piperid...)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibitory activity against fynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibitory activity against lynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibitory activity against hckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175212(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 2.35E+3nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175203(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175202(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 8.96E+3nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 9.05E+3nMAssay Description:Inhibitory activity against srcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175208(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 9.18E+3nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175210(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibitory activity against fynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibitory activity against fgrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175195(N-(4-(1-(1-(1-acetylpiperidin-4-yl)piperidin-4-yl)...)
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibitory activity against srcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175204(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 2.32E+4nMAssay Description:Inhibitory activity against lckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against ZAP70More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11/12/13/14(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against ITKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against IKK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against IKK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against PKCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against MK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha/beta/gamma(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against PKAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against IRAK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 8(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175196(N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEX...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibitory activity against COTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50175203(N-(4-(4-amino-1-(1-(tetrahydro-2H-pyran-4-yl)piper...)
Affinity DataIC50: 3.25E+4nMAssay Description:Inhibitory activity against fynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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