Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50016790
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173825(1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-t...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173822(1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173825(1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-t...)
Affinity DataEC50:  1.50E+3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173824(1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173822(1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-...)
Affinity DataEC50:  1.10E+3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173828(1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxami...)
Affinity DataEC50:  290nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173821(1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173827(1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173821(1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S...)
Affinity DataEC50:  1.30E+3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173828(1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxami...)
Affinity DataEC50:  24nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173827(1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...)
Affinity DataEC50:  410nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataEC50:  3nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173824(1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-...)
Affinity DataEC50: >1.00E+5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173826(1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propi...)
Affinity DataEC50:  0.5nMpH: 7.8Assay Description:Signaling (activation) potency for thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells with CREB-luciferase reporter upon incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173826(1-[(S)-2-Amino-3-(3-methyl-3H-imidazol-4-yl)-propi...)
Affinity DataKi:  3nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  10nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50072394(PROTIRELIN | ABBOTT-38579 | A-38579 | 1-[3-(1H-4-i...)
Affinity DataKi:  20nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173828(1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxami...)
Affinity DataKi:  320nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173828(1-[2-[5-oxo-(2S)-tetrahydro-1H-2-pyrrolylcarboxami...)
Affinity DataKi:  1.70E+4nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173824(1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173827(1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173821(1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173824(1-[3-{2-[1-(1-adamantyl)ethyl]-1H-4-imidazolyl}-2-...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173822(1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173825(1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-t...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 2 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173825(1-[3-(2-isopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-t...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173827(1-[3-(2-cyclopropyl-1H-4-imidazolyl)-2-[5-oxo-(2S)...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173822(1-[3-(2-cyclohexyl-1H-4-imidazolyl)-2-[5-oxo-(2S)-...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyrotropin-releasing hormone receptor(Rat)
National Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50173821(1-[3-[2-(tert-butyl)-1H-4-imidazolyl]-2-[5-oxo-(2S...)
Affinity DataKi: >1.00E+5nMpH: 7.4Assay Description:Inhibitory constant against thyrotropin releasing hormone receptor 1 expressed in HEK 293EM cells upon incubation at 37 degree C for 1 hr at pH 7.4 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed