Compile Data Set for Download or QSAR
Report error Found 24 Enz. Inhib. hit(s) with all data for entry = 50016536
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170205((R)-Phenyl-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2...)
Affinity DataIC50: 14nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170206(4-(4'-Acetyl-biphenyl-4-yl)-thiophene-2-carboxylic...)
Affinity DataIC50: 57nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170203((4-Biphenyl-4-yl-thiophene-2-carbonyl)-carbamic ac...)
Affinity DataIC50: 70nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170207([4-(2'-Hydroxy-biphenyl-4-yl)-thiophene-2-carbonyl...)
Affinity DataIC50: 70nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170201(4-(4-Pyridin-4-yl-phenyl)-thiophene-2-carboxylic a...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170201(4-(4-Pyridin-4-yl-phenyl)-thiophene-2-carboxylic a...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170211((R)-Phenyl-{[4-(4-trifluoromethoxy-phenyl)-thiophe...)
Affinity DataIC50: 180nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: 230nMAssay Description:Inhibition of Matrix metalloproteinase-12 in pressence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170205((R)-Phenyl-{[4-(4-pyridin-4-yl-phenyl)-thiophene-2...)
Affinity DataIC50: 270nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170210([4-(4-Trifluoromethoxy-phenyl)-thiophene-2-carbony...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170212([4-(4-Trifluoromethoxy-phenyl)-thiophene-2-carbony...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170209(4-Biphenyl-4-yl-thiophene-2-carboxylic acid (2-mor...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170208(4-(4-Cyclohexyl-phenyl)-thiophene-2-carboxylic aci...)
Affinity DataIC50: 460nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170203((4-Biphenyl-4-yl-thiophene-2-carbonyl)-carbamic ac...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170211((R)-Phenyl-{[4-(4-trifluoromethoxy-phenyl)-thiophe...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170207([4-(2'-Hydroxy-biphenyl-4-yl)-thiophene-2-carbonyl...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170204((S)-Phenyl-{[4-(4-trifluoromethoxy-phenyl)-thiophe...)
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of Matrix metalloprotease-12 in presence of 5 nM acetohydroximateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of Matrix metalloprotease-12More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of Matrix metalloprotease-13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50170202(4-(4-Methoxy-phenyl)-thiophene-2-carboxylic acid (...)
Affinity DataIC50: 1.01E+5nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed