Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50016407
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168624((S)-3-{[5-(2-Chloro-4-methyl-phenyl)-thiophene-2-c...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168622((S)-3-{[5-(4-Ethyl-phenyl)-thiophene-2-carbonyl]-m...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168618((S)-3-{[5-(4-Chloro-phenyl)-thiophene-2-carbonyl]-...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168616((S)-3-{[5-(2-Chloro-4-ethoxy-phenyl)-thiophene-2-c...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168611((S)-3-{Methyl-[5-(4-trifluoromethyl-phenyl)-thioph...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168615((S)-3-[(4'-Chloro-biphenyl-4-carbonyl)-methyl-amin...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168635((S)-3-{[5-(4-Methoxy-2-methyl-phenyl)-thiophene-2-...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168630((S)-3-{[5-(2,4-Dimethyl-phenyl)-thiophene-2-carbon...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168633((S)-3-[Methyl-(5-p-tolyl-thiophene-2-carbonyl)-ami...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168623((S)-3-{[5-(2,4-Dichloro-phenyl)-thiophene-2-carbon...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168605((S)-3-{[5-(4-Chloro-2-methyl-phenyl)-thiophene-2-c...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168628((S)-3-{[5-(4-Methoxy-phenyl)-thiophene-2-carbonyl]...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168631((S)-3-{Methyl-[5-(4-trifluoromethoxy-phenyl)-thiop...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168636((S)-3-{[5-(4-Isopropyl-phenyl)-thiophene-2-carbony...)
Affinity DataKi:  5nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168626((S)-3-[(4'-Methoxy-biphenyl-4-carbonyl)-methyl-ami...)
Affinity DataKi:  5nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168608((S)-3-{[5-(4-Dimethylamino-phenyl)-thiophene-2-car...)
Affinity DataKi:  7nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168613((S)-3-{[5-(2-Chloro-phenyl)-thiophene-2-carbonyl]-...)
Affinity DataKi:  10nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168610((S)-3-{Methyl-[5-(4-trifluoromethyl-phenyl)-thioph...)
Affinity DataKi:  14nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168619((S)-3-[(4'-Methoxy-2'-methyl-biphenyl-4-carbonyl)-...)
Affinity DataKi:  16nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168621((S)-3-[Methyl-(5-o-tolyl-thiophene-2-carbonyl)-ami...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168617((S)-3-{[5-(4-Fluoro-phenyl)-thiophene-2-carbonyl]-...)
Affinity DataKi:  37nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168632((S)-3-{Methyl-[5-(2-trifluoromethyl-phenyl)-thioph...)
Affinity DataKi:  61nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168607((S)-3-{[5-(4-Ethoxy-phenyl)-thiophene-2-carbonyl]-...)
Affinity DataKi:  63nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168625((R)-3-{Methyl-[5-(4-trifluoromethyl-phenyl)-thioph...)
Affinity DataKi:  150nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168620((R)-3-{Methyl-[5-(4-trifluoromethyl-phenyl)-thioph...)
Affinity DataKi:  190nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168614((S)-3-{[5-(2,6-Dimethyl-phenyl)-thiophene-2-carbon...)
Affinity DataKi:  310nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168609((S)-3-{[5-(3-Chloro-phenyl)-thiophene-2-carbonyl]-...)
Affinity DataKi:  320nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168629((S)-3-{[5-(3-Methoxy-phenyl)-thiophene-2-carbonyl]...)
Affinity DataKi:  900nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168606((S)-3-{Methyl-[5-(3-trifluoromethyl-phenyl)-thioph...)
Affinity DataKi:  1.80E+3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168627((S)-3-{[5-(4-Cyano-phenyl)-thiophene-2-carbonyl]-m...)
Affinity DataKi:  2.40E+3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168634((S)-3-{[5-(4-Isopropoxy-phenyl)-thiophene-2-carbon...)
Affinity DataKi:  3.30E+3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168612((S)-3-{[5-(2-Methoxy-phenyl)-thiophene-2-carbonyl]...)
Affinity DataKi:  3.40E+3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168603((S)-3-{[5-(4-Methanesulfonyl-phenyl)-thiophene-2-c...)
Affinity DataKi:  6.00E+3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168604((S)-3-{[5-(4-Hydroxy-phenyl)-thiophene-2-carbonyl]...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed