Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 1834
LigandPNGBDBM14423(4-{[3-(3-ethoxyphenyl)-1-methyl-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 0.650nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14419(4-{[3-(3-chlorophenyl)-1-methyl-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.40nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14421(4-{hydroxy[3-(3-methoxyphenyl)-1-methyl-2-oxo-2,3-...)
Affinity DataIC50: 5.10nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14429(4-({3-[(3-chlorophenyl)methyl]-1-methyl-2-oxo-2,3-...)
Affinity DataIC50: 5.20nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14422(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50: 6.60nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14420(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50: 6.70nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14425(4-{[3-(2H-1,3-benzodioxol-5-yl)-1-methyl-2-oxo-2,3...)
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14433(4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4....)
Affinity DataIC50: 8.30nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14417(3-(3-chlorophenyl)-5-[(4-chlorophenyl)(hydroxy)(1-...)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14426(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50: 21nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14418(3-(3-chlorophenyl)-5-[hydroxy(4-iodophenyl)(1-meth...)
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14430((4-chlorophenyl)[1-(3-chlorophenyl)-1H-indol-6-yl]...)
Affinity DataIC50: 36nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14428(3-[(3-chlorophenyl)methyl]-5-[hydroxy(4-iodophenyl...)
Affinity DataIC50: 71nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14424(3-(2H-1,3-benzodioxol-5-yl)-5-[(4-chlorophenyl)(hy...)
Affinity DataIC50: 150nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14427(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50: 150nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14431((4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)[1-(nap...)
Affinity DataIC50: 200nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14434(Racemic mixture | R-115777 | 6-[amino(4-chlorophen...)
Affinity DataIC50: 1.10E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14432(1-(3-chlorophenyl)-5-[(4-chlorophenyl)(hydroxy)(1-...)
Affinity DataIC50: 1.10E+3nMpH: 7.5 T: 2°CAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14418(3-(3-chlorophenyl)-5-[hydroxy(4-iodophenyl)(1-meth...)
Affinity DataIC50: 1.20E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14419(4-{[3-(3-chlorophenyl)-1-methyl-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.80E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14426(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50: 2.90E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14429(4-({3-[(3-chlorophenyl)methyl]-1-methyl-2-oxo-2,3-...)
Affinity DataIC50: 5.60E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14422(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50: 7.50E+3nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14420(5-[(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14421(4-{hydroxy[3-(3-methoxyphenyl)-1-methyl-2-oxo-2,3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14423(4-{[3-(3-ethoxyphenyl)-1-methyl-2-oxo-2,3-dihydro-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14425(4-{[3-(2H-1,3-benzodioxol-5-yl)-1-methyl-2-oxo-2,3...)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM14433(4-[2-(4-{6,15-dibromo-13-chloro-4-azatricyclo[9.4....)
Affinity DataIC50: 1.00E+4nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14417(3-(3-chlorophenyl)-5-[(4-chlorophenyl)(hydroxy)(1-...)
Affinity DataIC50: 1.10E+4nMAssay Description:The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed