Compile Data Set for Download or QSAR
Report error Found 29 Enz. Inhib. hit(s) with all data for entry = 50037494
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human phosphodiesterase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14776(CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50: 120nMAssay Description:Inhibition of human phosphodiesterase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataIC50: 350nMAssay Description:Inhibition of human phosphodiesterase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50027175(CHEMBL364291)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human phosphodiesterase 3; Range = 0.5-2 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50027175(CHEMBL364291)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human phosphodiesterase 4; Range = 0.8-4 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
LigandPNGBDBM14363(5-(2-propoxyphenyl)-2H,3H,7H-[1,2,3]triazolo[4,5-d...)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human phosphodiesterase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14363(5-(2-propoxyphenyl)-2H,3H,7H-[1,2,3]triazolo[4,5-d...)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibitory concentration value against phosphodiesterase 10More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibitory concentration against phosphodiesterase-11More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14776(CHEMBL1520 | 2-{2-ethoxy-5-[(4-ethylpiperazine-1-)...)
Affinity DataKi:  1nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataKi:  10nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14777(CHEMBL779 | (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2-m...)
Affinity DataKi:  10nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50027177(Cilostamide)
Affinity DataKi:  20nMAssay Description:Inhibition of human phosphodiesterase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14390(SILDENAFIL CITRATE | Sildenafil# | CHEMBL192 | 5-[...)
Affinity DataKi:  50nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM23620(Dipyridamine | SMR000058382 | MLS000028420 | CHEMB...)
Affinity DataKi:  125nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14363(5-(2-propoxyphenyl)-2H,3H,7H-[1,2,3]triazolo[4,5-d...)
Affinity DataKi:  130nMAssay Description:Inhibition of human phosphodiesterase 5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM15296(Milrinone | CHEMBL189 | 6-methyl-2-oxo-5-pyridin-4...)
Affinity DataKi:  150nMAssay Description:Inhibition of human phosphodiesterase 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetO43924/P16499/P18545/P35913/P51160/Q13956(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14363(5-(2-propoxyphenyl)-2H,3H,7H-[1,2,3]triazolo[4,5-d...)
Affinity DataKi:  400nMAssay Description:Inhibition of human phosphodiesterase 6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM23620(Dipyridamine | SMR000058382 | MLS000028420 | CHEMB...)
Affinity DataKi:  400nMAssay Description:Inhibition of human phosphodiesterase 11More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
LigandPNGBDBM23620(Dipyridamine | SMR000058382 | MLS000028420 | CHEMB...)
Affinity DataKi:  600nMAssay Description:Inhibition of human phosphodiesterase 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM23620(Dipyridamine | SMR000058382 | MLS000028420 | CHEMB...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibitory activity against phosphodiesterase 10More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50034908((2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol | 3-(6-A...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human phosphodiesterase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of human phosphodiesterase 4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50027176(CHEBI:34795 | 2-Acetoxy-Benzoic Acid | 3-Isobutyl-...)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human phosphodiesterase 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14363(5-(2-propoxyphenyl)-2H,3H,7H-[1,2,3]triazolo[4,5-d...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibition of human phosphodiesterase 11More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
LigandPNGBDBM50059033(CHEMBL71752 | cid_443955 | (11aS,11bS)-11a-Ethyl-2...)
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of human phosphodiesterase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM14363(5-(2-propoxyphenyl)-2H,3H,7H-[1,2,3]triazolo[4,5-d...)
Affinity DataKi:  3.50E+4nMAssay Description:Inhibition of human phosphodiesterase 9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed