Compile Data Set for Download or QSAR
Report error Found 9 Enz. Inhib. hit(s) with all data for entry = 2175
TargetGlutamate carboxypeptidase 2 [44-750](Human)
Guilford Pharmaceuticals

LigandPNGBDBM17759(pentanedioic acid analogue, (S)-1 | (2S)-2-(phosph...)
Affinity DataIC50: 0.100nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2 [44-750](Human)
Guilford Pharmaceuticals

LigandPNGBDBM17659(pentanedioic acid analogue, (RS)-1 | 2-(phosphonom...)
Affinity DataIC50: 0.300nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate carboxypeptidase 2 [44-750](Human)
Guilford Pharmaceuticals

LigandPNGBDBM17758(pentanedioic acid analogue, (R)-1 | (2R)-2-(phosph...)
Affinity DataIC50: 30nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2 [44-750](Human)
Guilford Pharmaceuticals

LigandPNGBDBM17754((2S)-2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)meth...)
Affinity DataIC50: 34nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2 [44-750](Human)
Guilford Pharmaceuticals

LigandPNGBDBM17757((2S)-2-(3-sulfanylpropyl)pentanedioic acid | penta...)
Affinity DataIC50: 67nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2 [44-750](Human)
Guilford Pharmaceuticals

LigandPNGBDBM17752(CHEMBL64901 | 2-({hydroxy[(2,3,4,5,6-pentafluoroph...)
Affinity DataIC50: 82nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2 [44-750](Human)
Guilford Pharmaceuticals

LigandPNGBDBM17756((2R)-2-(3-sulfanylpropyl)pentanedioic acid | penta...)
Affinity DataIC50: 85nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2 [44-750](Human)
Guilford Pharmaceuticals

LigandPNGBDBM17755(pentanedioic acid analogue, (RS)-3 | CHEMBL303352 ...)
Affinity DataIC50: 90nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2 [44-750](Human)
Guilford Pharmaceuticals

LigandPNGBDBM17753((2R)-2-({hydroxy[(2,3,4,5,6-pentafluorophenyl)meth...)
Affinity DataIC50: 1.40E+3nMpH: 7.4 T: 2°CAssay Description:GCPII activity in vitro is monitored through the hydrolysis [3H]NAAG to NAA and [3H]Glu. The radioactivity-based assay was miniaturized to a 96-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2007
Entry Details Article
PubMed