Compile Data Set for Download or QSAR
Report error Found 22 Enz. Inhib. hit(s) with all data for entry = 50015820
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161313(N-{[Methyl-((S)-1-phenyl-2-pyrrolidin-1-yl-ethyl)-...)
Affinity DataEC50:  3.85nMAssay Description:In vitro effective concentration towards human kappa opioid receptor was determined using [35S]-GTP-gamma S as radioligand; Not determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161316(1-Oxy-benzo[1,2,5]oxadiazole-5-carboxylic acid {[m...)
Affinity DataEC50:  4.37nMAssay Description:In vitro effective concentration towards human kappa opioid receptor was determined using [35S]-GTP-gamma S as radioligand; Not determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161315(N-({[(S)-2-((R)-3-Hydroxy-pyrrolidin-1-yl)-1-pheny...)
Affinity DataEC50:  1.98nMAssay Description:In vitro effective concentration towards human kappa opioid receptor was determined using [35S]-GTP-gamma S as radioligand; Not determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161317(3,4-Dichloro-N-({[(S)-2-((R)-3-hydroxy-pyrrolidin-...)
Affinity DataEC50:  0.760nMAssay Description:In vitro effective concentration towards human kappa opioid receptor was determined using [35S]-GTP-gamma S as radioligand; Not determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161320(3,4-Dichloro-N-{[methyl-((S)-1-phenyl-2-pyrrolidin...)
Affinity DataEC50:  2.25nMAssay Description:In vitro effective concentration towards human kappa opioid receptor was determined using [35S]-GTP-gamma S as radioligand; Not determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161318(3,4-Dichloro-N-({[(S)-2-((R)-3-hydroxy-pyrrolidin-...)
Affinity DataEC50:  41.4nMAssay Description:In vitro effective concentration towards human kappa opioid receptor was determined using [35S]-GTP-gamma S as radioligand; Not determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50007344(2-(3,4-Dichloro-phenyl)-N-methyl-N-(1-phenyl-2-pyr...)
Affinity DataKi:  0.0430nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161317(3,4-Dichloro-N-({[(S)-2-((R)-3-hydroxy-pyrrolidin-...)
Affinity DataKi:  0.830nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161315(N-({[(S)-2-((R)-3-Hydroxy-pyrrolidin-1-yl)-1-pheny...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161320(3,4-Dichloro-N-{[methyl-((S)-1-phenyl-2-pyrrolidin...)
Affinity DataKi:  3.60nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161316(1-Oxy-benzo[1,2,5]oxadiazole-5-carboxylic acid {[m...)
Affinity DataKi:  4.60nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161313(N-{[Methyl-((S)-1-phenyl-2-pyrrolidin-1-yl-ethyl)-...)
Affinity DataKi:  6.70nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161314(N-{[Methyl-((S)-1-phenyl-2-pyrrolidin-1-yl-ethyl)-...)
Affinity DataKi:  16.3nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161318(3,4-Dichloro-N-({[(S)-2-((R)-3-hydroxy-pyrrolidin-...)
Affinity DataKi:  20nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161311(N-({[(S)-2-((R)-3-Hydroxy-pyrrolidin-1-yl)-1-pheny...)
Affinity DataKi:  48nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161312({[Methyl-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-carbam...)
Affinity DataKi:  84nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161325((S)N-{[Methyl-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-c...)
Affinity DataKi:  99nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161322((RorS){[Methyl-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-...)
Affinity DataKi:  138nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161323((S){1-[Methyl-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-c...)
Affinity DataKi:  150nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161319((S){[Methyl-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-car...)
Affinity DataKi:  178nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161321((R,S)2-Formylamino-N-methyl-2-phenyl-N-(1-phenyl-2...)
Affinity DataKi:  258nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50161324((RorS){[Methyl-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-...)
Affinity DataKi:  856nMAssay Description:In vitro binding affinity for human kappa opioid receptor was determined by using [3H]diprenorphine as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed