Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 50000404
TargetMuscarinic acetylcholine receptor(Guinea pig)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363(3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2...)
Affinity DataEC50:  16nMAssay Description:In vitro contraction of guinea pig myenteric plexus preparation (mediated by Muscarinic M3 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005364(CHEMBL171721 | (3S,4R)3-Methyl-3-(3-methyl-[1,2,4]...)
Affinity DataEC50:  110nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion (mediated by muscarinic acetylcholine receptor M1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363(3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2...)
Affinity DataEC50:  3.30nMAssay Description:In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor(Guinea pig)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005364(CHEMBL171721 | (3S,4R)3-Methyl-3-(3-methyl-[1,2,4]...)
Affinity DataEC50:  13nMAssay Description:In vitro contraction of guinea pig myenteric plexus preparation (mediated by muscarinic acetylcholine receptor M3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363(3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2...)
Affinity DataEC50:  19nMAssay Description:In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363(3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2...)
Affinity DataEC50:  19nMAssay Description:In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363(3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2...)
Affinity DataEC50:  2.40nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion (mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor(Guinea pig)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363(3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2...)
Affinity DataEC50:  16nMAssay Description:In vitro contraction of guinea pig myenteric plexus preparation (mediated by Muscarinic M3 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005364(CHEMBL171721 | (3S,4R)3-Methyl-3-(3-methyl-[1,2,4]...)
Affinity DataEC50:  14nMAssay Description:In vitro negative chronotropic effect on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor(Guinea pig)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363(3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2...)
Affinity DataEC50:  2.40nMAssay Description:In vitro contraction of guinea pig myenteric plexus preparation (mediated by Muscarinic M3 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363(3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2...)
Affinity DataEC50:  7nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion (mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363(3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bicyclo[2...)
Affinity DataEC50:  7nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion (mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed