Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 2695
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2008
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 4.70nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2008
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 6.60nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2008
Entry Details Article
PubMed
LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 8.40nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2008
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wyeth Research

LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 12nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2008
Entry Details Article
PubMed
TargetMatrilysin(Human)
Wyeth Research

LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 26nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2008
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 26nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2008
Entry Details Article
PubMed
LigandPNGBDBM23498((3S)-4-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}-N-h...)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2008
Entry Details Article
PubMed