Compile Data Set for Download or QSAR
Report error Found 60 Enz. Inhib. hit(s) with all data for entry = 50014103
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138288(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138291((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138304((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataEC50:  89nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138302(N-[1-(2-{4-[(S)-2-(4-Chloro-benzyl)-4-oxo-4-thiazo...)
Affinity DataEC50:  530nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138301(4-[(S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phen...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138294(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138290((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138299((S)-4-(4-Acetyl-piperazin-1-yl)-2-(4-chloro-benzyl...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138293((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataEC50:  74nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138297((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataEC50:  37nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138296((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataEC50:  15nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50134495(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Affinity DataEC50:  5.20nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138305((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138292((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataEC50: >1.00E+4nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50223719(CHEMBL3348530)
Affinity DataEC50: <0.0100nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138303((S)-4-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-benzy...)
Affinity DataEC50:  83nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138295((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataEC50:  2.00E+3nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138300(N-[1-(2-{4-[(S)-4-Azetidin-1-yl-2-(4-chloro-benzyl...)
Affinity DataEC50:  340nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138298(Piperidine-4-carboxylic acid ((R)-1-(4-chloro-benz...)
Affinity DataEC50: <0.100nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50223719(CHEMBL3348530)
Affinity DataIC50: 0.0600nMAssay Description:Inhibitory activity against mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138293((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: 0.100nMAssay Description:Inhibitory activity against [125I]NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50223719(CHEMBL3348530)
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity against [125I]NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138288(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Affinity DataIC50: 1.40nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138301(4-[(S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phen...)
Affinity DataIC50: 2nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138290((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: 3nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138294(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Affinity DataIC50: 3.30nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138303((S)-4-(4-Benzoyl-piperazin-1-yl)-2-(4-chloro-benzy...)
Affinity DataIC50: 4.40nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138305((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: 4.80nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138296((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataIC50: 5.80nMAssay Description:Inhibitory activity against [125I]NDP-alpha-MSH binding to the human melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138292((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: 8.90nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138302(N-[1-(2-{4-[(S)-2-(4-Chloro-benzyl)-4-oxo-4-thiazo...)
Affinity DataIC50: 9.40nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138291((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: 9.5nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138299((S)-4-(4-Acetyl-piperazin-1-yl)-2-(4-chloro-benzyl...)
Affinity DataIC50: 11nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138304((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataIC50: 13nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138300(N-[1-(2-{4-[(S)-4-Azetidin-1-yl-2-(4-chloro-benzyl...)
Affinity DataIC50: 19nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138297((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataIC50: 32nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50223719(CHEMBL3348530)
Affinity DataIC50: 44nMAssay Description:Inhibitory activity against human melanocortin 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50134495(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Affinity DataIC50: 66nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138298(Piperidine-4-carboxylic acid ((R)-1-(4-chloro-benz...)
Affinity DataIC50: 130nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50134495(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Affinity DataIC50: 153nMAssay Description:Inhibitory activity against mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138295((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: 220nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50138296((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50138300(N-[1-(2-{4-[(S)-4-Azetidin-1-yl-2-(4-chloro-benzyl...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50138304((S)-4-(4-{2-[1-(Acetyl-ethyl-amino)-ethyl]-phenyl}...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory activity against mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50138293((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibitory activity against mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50134495(1'-[3-(4-chlorophenyl)-2-[(3R)-1,2-dihydro-3-isoqu...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibitory activity against human melanocortin 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138294(4-((S)-3-(4-Chloro-benzyl)-4-{4-[2-(2-cyclopropyl-...)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibitory activity against human melanocortin 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138295((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against human melanocortin 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50138295((S)-2-(4-Chloro-benzyl)-1-{4-[2-(2-cyclopropyl-1-m...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against mouse melanocortin 1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50138300(N-[1-(2-{4-[(S)-4-Azetidin-1-yl-2-(4-chloro-benzyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against human melanocortin 3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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