Compile Data Set for Download or QSAR
Report error Found 37 Enz. Inhib. hit(s) with all data for entry = 50037148
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50097370(4-Bromo-1-imidazol-1-ylmethyl-xanthen-9-one | 1-((...)
Affinity DataIC50: 42nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50063477((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...)
Affinity DataIC50: 50nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50215709(CHEMBL1170 | Propionic acid 10,13-dimethyl-3-oxo-2...)
Affinity DataIC50: 56nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50097363(1-Imidazol-1-ylmethyl-4-nitro-xanthen-9-one | 1-((...)
Affinity DataIC50: 130nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50063475((10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-1,2,6,7,...)
Affinity DataIC50: 150nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128550(NRB 03731 | CHEMBL77751)
Affinity DataIC50: 178nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50097365(1-((1H-imidazol-1-yl)methyl)-9-oxo-9H-xanthene-4-c...)
Affinity DataIC50: 220nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128565((3S,10R,13S,17R)-10,13-Dimethyl-17-pyrimidin-4-yl-...)
Affinity DataIC50: 225nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128564((3S,10R,13S)-17-Benzoimidazol-1-yl-10,13-dimethyl-...)
Affinity DataIC50: 300nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50409697(CHEMBL2112282)
Affinity DataIC50: 320nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50063476((3S,10R,13S)-10,13-Dimethyl-17-[1,2,3]triazol-1-yl...)
Affinity DataIC50: 377nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50063479((10R,13S)-10,13-Dimethyl-17-[1,2,3]triazol-1-yl-1,...)
Affinity DataIC50: 387nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128563(((3S,10R,13R)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8,9...)
Affinity DataIC50: 450nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128543((3S,10R,13S)-10,13-Dimethyl-17-pyrimidin-5-yl-2,3,...)
Affinity DataIC50: 500nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128551(Acetic acid (10R,13S,17S)-10,13,17-trimethyl-2-met...)
Affinity DataIC50: 562nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128556((R)-4-((3S,10R)-3-Hydroxy-10-methyl-2,3,4,7,8,9,10...)
Affinity DataIC50: 617nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128546((3S,10R,13R)-3-Hydroxy-10,13-dimethyl-1,2,3,4,7,8,...)
Affinity DataIC50: 628nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128560(Acetic acid (10R,13S,17S)-10,13-dimethyl-3-oxo-8,9...)
Affinity DataIC50: 660nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50063480((3S,10R,13S)-10,13-Dimethyl-17-[1,2,4]triazol-1-yl...)
Affinity DataIC50: 800nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM25458(ABT | CHEMBL254328 | CB 7598 | (1S,2R,5S,10R,11S,1...)
Affinity DataIC50: 800nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128544((10R,13S)-17-Benzoimidazol-1-yl-10,13-dimethyl-1,2...)
Affinity DataIC50: 915nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50061172((10R,13S)-17-Isoxazol-5-yl-10,13-dimethyl-1,2,6,7,...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50063478((10R,13S)-10,13-Dimethyl-17-[1,2,4]triazol-1-yl-1,...)
Affinity DataIC50: 1.20E+3nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128552((3S,10R,13S)-17-Benzotriazol-1-yl-10,13-dimethyl-2...)
Affinity DataIC50: 1.25E+3nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128561((3S,10R,13S)-10,13-Dimethyl-17-tetrazol-2-yl-2,3,4...)
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50409695(CHEMBL2112280)
Affinity DataIC50: 1.70E+3nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128555((3S,10R,13S)-10,13-Dimethyl-17-tetrazol-1-yl-2,3,4...)
Affinity DataIC50: 2.60E+3nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128547((3S,10R,13S)-10,13-Dimethyl-17-[1,2,3]triazol-2-yl...)
Affinity DataIC50: 3.70E+3nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128542((3S,10R,13S)-10,13-Dimethyl-17-pyrazin-2-yl-2,3,4,...)
Affinity DataIC50: 3.81E+3nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128557((3S,10R,13S)-17-Hydrazono-3-hydroxy-10,13-dimethyl...)
Affinity DataIC50: 5.90E+3nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50409696(CHEMBL2112281)
Affinity DataIC50: 1.21E+4nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128548(1-(Biphenyl-4-yl-phenyl-methyl)-1H-imidazole (bifo...)
Affinity DataKi:  56.5nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM31774(cid_2812 | CHEMBL104 | Canesten | Mycelex | Lotrim...)
Affinity DataKi:  81.5nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM31772(Brentan | 1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dich...)
Affinity DataKi:  243nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM31773(ECONAZOLE | cid_68589 | Pevaryl | Gyno-pevaryl | E...)
Affinity DataKi:  325nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50370218(TIOCONAZOLE)
Affinity DataKi:  505nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Accelrys

Curated by ChEMBL
LigandPNGBDBM50128554(1-(2,6-Dichloro-phenyl)-2-(2,4-dichloro-phenyl)-3-...)
Affinity DataKi:  610nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed