Compile Data Set for Download or QSAR
Report error Found 16 Enz. Inhib. hit(s) with all data for entry = 50037241
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataEC50:  1.20E+3nMAssay Description:Ability to enhance currents from alpha-1-beta-2-gamma-2L-subunit of GABA receptor elicited by low concentrations of GABAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataEC50:  3.70E+4nMAssay Description:Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125939(3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataEC50:  2.00E+4nMAssay Description:Enhancement of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataEC50:  6.40E+4nMAssay Description:Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataEC50:  2.00E+3nMAssay Description:Enhancement of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125937(CHEMBL279678 | 3-((S)-1-Phenyl-ethyl)-3H-imidazole...)
Affinity DataEC50:  4.70E+4nMAssay Description:Enhancement of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataEC50:  2.50E+3nMAssay Description:Enhancement of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataEC50:  1.20E+3nMAssay Description:Ability to enhance currents from alpha-1-beta-2-gamma-2L-subunit of GABA receptor elicited by low concentrations of GABAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125934(3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Pacific electric ray)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAcetylcholine receptor subunit alpha/beta/delta/gamma(Mouse)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125939(3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataIC50: 6.63E+4nMAssay Description:Inhibition of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125936(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Affinity DataIC50: 1.04E+5nMAssay Description:Inhibition of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125937(CHEMBL279678 | 3-((S)-1-Phenyl-ethyl)-3H-imidazole...)
Affinity DataIC50: 2.95E+5nMAssay Description:Inhibition of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50125935(CHEMBL681 | R(+)-etomidate | Amidate | (R)-1-(1-ph...)
Affinity DataIC50: 5.77E+5nMAssay Description:Inhibition of currents elicited by GABA at EC5 (6-12 uM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)