Compile Data Set for Download or QSAR
Report error Found 30 Enz. Inhib. hit(s) with all data for entry = 50012820
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123052(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxol...)
Affinity DataEC50:  62nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  2nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataEC50:  2nMAssay Description:Effective concentration binding towards TRalpha in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123052(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxol...)
Affinity DataEC50:  1.50E+3nMAssay Description:Effective concentration binding towards TRalpha in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor alpha(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123044(5-[2,6-Dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4...)
Affinity DataEC50:  12nMAssay Description:Effective concentration binding towards TRalpha in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123058(2-{3,5-Dichloro-4-[4-hydroxy-3-(piperidine-1-sulfo...)
Affinity DataKi:  0.0200nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123046([4-(4-HYDROXY-3-ISOPROPYL-PHENOXY)-3,5-DIMETHYL-PH...)
Affinity DataKi:  0.0300nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123044(5-[2,6-Dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4...)
Affinity DataKi:  0.0400nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123044(5-[2,6-Dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4...)
Affinity DataKi:  0.0400nMAssay Description:Inhibitory activity against [125I]T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123045(N-Cyclohexyl-5-[2,6-dichloro-4-(3,5-dioxo-4,5-dihy...)
Affinity DataKi:  0.0700nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM18860(triothyrone | (2S)-2-amino-3-[4-(4-hydroxy-3-iodop...)
Affinity DataKi:  0.0800nMAssay Description:Inhibitory activity against [125I]T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123054(5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-tri...)
Affinity DataKi:  0.100nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123064(2-{3-Chloro-4-[4-hydroxy-3-(piperidine-1-sulfonyl)...)
Affinity DataKi:  0.130nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123063(2-{3,5-Dichloro-4-[4-hydroxy-3-(indole-1-sulfonyl)...)
Affinity DataKi:  0.230nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123052(2-[4-(3-{8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxol...)
Affinity DataKi:  0.280nMAssay Description:Inhibitory activity against [125I]T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123061(2-{3,5-dichloro-4-[4-hydroxy-3-spiro[8-azabicyclo[...)
Affinity DataKi:  0.310nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123059(2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4...)
Affinity DataKi:  0.370nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123059(2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4...)
Affinity DataKi:  0.370nMAssay Description:Inhibitory activity against [125I]T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123057(N-cyclobutyl-5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihy...)
Affinity DataKi:  0.400nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123056(2-{4-[4-Hydroxy-3-(piperidine-1-sulfonyl)-phenoxy]...)
Affinity DataKi:  0.460nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123062(N-Cyclohexyl-5-[2,6-dichloro-4-(3,5-dioxo-4,5-dihy...)
Affinity DataKi:  0.460nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123059(2-{4-[3-(2-Aza-bicyclo[2.2.1]heptane-2-carbonyl)-4...)
Affinity DataKi:  0.590nMAssay Description:Inhibitory activity against [125I]T3 binding to human TRbeta1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123049(2-{3,5-Dichloro-4-[4-hydroxy-3-(piperidine-1-carbo...)
Affinity DataKi:  0.630nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123050(N-cyclobutyl-5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihy...)
Affinity DataKi:  0.640nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123055(2-(3,5-dichloro-4-(4-hydroxy-3-(morpholine-4-carbo...)
Affinity DataKi:  0.720nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123060(2-{3-Chloro-4-[4-hydroxy-3-(piperidine-1-carbonyl)...)
Affinity DataKi:  1.90nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123053(2-[3,5-Dimethyl-4-(3-methyl-4-methylsulfanyl-pheno...)
Affinity DataKi:  2nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123047(2-{3-Chloro-4-[4-hydroxy-3-(4-methyl-piperazine-1-...)
Affinity DataKi:  13nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123048(2-{3-Chloro-4-[4-hydroxy-3-(morpholine-4-sulfonyl)...)
Affinity DataKi:  27nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThyroid hormone receptor beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123051(1-[4-(4-Hydroxy-3-isopropyl-phenoxy)-3,5-dimethyl-...)
Affinity DataKi:  1.00E+4nMAssay Description:Effective concentration binding towards TR-beta-1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed