Compile Data Set for Download or QSAR
Report error Found 73 Enz. Inhib. hit(s) with all data for entry = 50012584
LigandPNGBDBM26526(BMCL181958 Compound 1 | CHEMBL148169 | (2R)-N-hydr...)
Affinity DataIC50: 1nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120698(N-Hydroxy-2-{3-methyl-2-oxo-3-[4-(quinolin-4-ylmet...)
Affinity DataIC50: 1.80nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120689((R)-2-((S)-3-(4-(3,5-bis(trifluoromethyl)benzyloxy...)
Affinity DataIC50: 2nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120698(N-Hydroxy-2-{3-methyl-2-oxo-3-[4-(quinolin-4-ylmet...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of Tumor necrosis factor alpha secretion in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120692(2-{3-[4-(3,5-Dimethyl-benzyloxy)-phenyl]-3-methyl-...)
Affinity DataIC50: 4nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120687(N-Hydroxy-2-{3-methyl-3-[4-(2-nitro-benzyloxy)-phe...)
Affinity DataIC50: 4nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120696((R)-2-((S)-3-(4-(benzyloxy)phenyl)-3-methyl-2-oxop...)
Affinity DataIC50: 4nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120699(N-Hydroxy-2-{3-methyl-2-oxo-3-[4-(pyridin-4-ylmeth...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of Tumor necrosis factor alpha secretion in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120690(N-Hydroxy-2-{3-methyl-3-[4-(3-nitro-benzyloxy)-phe...)
Affinity DataIC50: 6nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120693(N-Hydroxy-2-{3-methyl-3-[4-(4-nitro-benzyloxy)-phe...)
Affinity DataIC50: 6nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120695(2-{3-[4-(3,5-Dimethoxy-benzyloxy)-phenyl]-3-methyl...)
Affinity DataIC50: 7nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120684(2-{3-[4-(3,5-Dimethyl-pyridin-4-ylmethoxy)-phenyl]...)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of Tumor necrosis factor alpha secretion in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120684(2-{3-[4-(3,5-Dimethyl-pyridin-4-ylmethoxy)-phenyl]...)
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against porcine Tumor necrosis factor alpha converting enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120684(2-{3-[4-(3,5-Dimethyl-pyridin-4-ylmethoxy)-phenyl]...)
Affinity DataIC50: 16nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120699(N-Hydroxy-2-{3-methyl-2-oxo-3-[4-(pyridin-4-ylmeth...)
Affinity DataIC50: 21nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120685(2-[3-(4-Allyloxy-phenyl)-3-methyl-2-oxo-pyrrolidin...)
Affinity DataIC50: 97nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataIC50: 185nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM26526(BMCL181958 Compound 1 | CHEMBL148169 | (2R)-N-hydr...)
Affinity DataIC50: 350nMAssay Description:Inhibition of Tumor necrosis factor alpha secretion in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120688(N-Hydroxy-2-[3-(4-methoxy-phenyl)-3-methyl-2-oxo-p...)
Affinity DataIC50: 887nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120686(N-Hydroxy-2-[3-(4-isobutyl-phenyl)-3-methyl-2-oxo-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120694(N-Hydroxy-2-(3-methyl-2-oxo-3-phenyl-pyrrolidin-1-...)
Affinity DataIC50: 2.20E+3nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50120697(2-[3-(4-tert-Butoxy-phenyl)-3-methyl-2-oxo-pyrroli...)
Affinity DataIC50: 1.00E+4nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50247572((R)-2-((S)-3-(biphenyl-4-yl)-3-methyl-2-oxopyrroli...)
Affinity DataIC50: 1.30E+4nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM26526(BMCL181958 Compound 1 | CHEMBL148169 | (2R)-N-hydr...)
Affinity DataKi:  0.560nMAssay Description:Affinity for Tumor necrosis factor alpha converting enzyme (TACE)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataKi: <2.10nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataKi: <2.80nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120688(N-Hydroxy-2-[3-(4-methoxy-phenyl)-3-methyl-2-oxo-p...)
Affinity DataKi:  4.80nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120688(N-Hydroxy-2-[3-(4-methoxy-phenyl)-3-methyl-2-oxo-p...)
Affinity DataKi:  9nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120685(2-[3-(4-Allyloxy-phenyl)-3-methyl-2-oxo-pyrrolidin...)
Affinity DataKi:  11nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120693(N-Hydroxy-2-{3-methyl-3-[4-(4-nitro-benzyloxy)-phe...)
Affinity DataKi:  11nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120685(2-[3-(4-Allyloxy-phenyl)-3-methyl-2-oxo-pyrrolidin...)
Affinity DataKi:  14nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120696((R)-2-((S)-3-(4-(benzyloxy)phenyl)-3-methyl-2-oxop...)
Affinity DataKi:  19nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120696((R)-2-((S)-3-(4-(benzyloxy)phenyl)-3-methyl-2-oxop...)
Affinity DataKi:  29nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50247572((R)-2-((S)-3-(biphenyl-4-yl)-3-methyl-2-oxopyrroli...)
Affinity DataKi:  35nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120687(N-Hydroxy-2-{3-methyl-3-[4-(2-nitro-benzyloxy)-phe...)
Affinity DataKi:  35nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120690(N-Hydroxy-2-{3-methyl-3-[4-(3-nitro-benzyloxy)-phe...)
Affinity DataKi:  38nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120690(N-Hydroxy-2-{3-methyl-3-[4-(3-nitro-benzyloxy)-phe...)
Affinity DataKi:  39nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120693(N-Hydroxy-2-{3-methyl-3-[4-(4-nitro-benzyloxy)-phe...)
Affinity DataKi:  40nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120687(N-Hydroxy-2-{3-methyl-3-[4-(2-nitro-benzyloxy)-phe...)
Affinity DataKi:  66nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50247572((R)-2-((S)-3-(biphenyl-4-yl)-3-methyl-2-oxopyrroli...)
Affinity DataKi:  82nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120688(N-Hydroxy-2-[3-(4-methoxy-phenyl)-3-methyl-2-oxo-p...)
Affinity DataKi:  92nMAssay Description:Affinity towards Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120694(N-Hydroxy-2-(3-methyl-2-oxo-3-phenyl-pyrrolidin-1-...)
Affinity DataKi:  108nMAssay Description:Affinity for Matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM26526(BMCL181958 Compound 1 | CHEMBL148169 | (2R)-N-hydr...)
Affinity DataKi:  141nMAssay Description:Affinity for Matrix metalloprotease-3 (MMP-3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120691((R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyph...)
Affinity DataKi:  143nMAssay Description:Affinity towards Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120694(N-Hydroxy-2-(3-methyl-2-oxo-3-phenyl-pyrrolidin-1-...)
Affinity DataKi:  221nMAssay Description:Affinity towards Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120694(N-Hydroxy-2-(3-methyl-2-oxo-3-phenyl-pyrrolidin-1-...)
Affinity DataKi:  242nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM26526(BMCL181958 Compound 1 | CHEMBL148169 | (2R)-N-hydr...)
Affinity DataKi:  257nMAssay Description:Affinity for Matrix metalloprotease-8 (MMP-8)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM26526(BMCL181958 Compound 1 | CHEMBL148169 | (2R)-N-hydr...)
Affinity DataKi:  259nMAssay Description:Affinity for Matrix metalloprotease-7 (MMP-7)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120685(2-[3-(4-Allyloxy-phenyl)-3-methyl-2-oxo-pyrrolidin...)
Affinity DataKi:  335nMAssay Description:Affinity towards Matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50120686(N-Hydroxy-2-[3-(4-isobutyl-phenyl)-3-methyl-2-oxo-...)
Affinity DataKi:  586nMAssay Description:Affinity towards Matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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