Compile Data Set for Download or QSAR
Report error Found 78 Enz. Inhib. hit(s) with all data for entry = 50011987
LigandPNGBDBM50113040((2R,4R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113041((2R,5R)-5-Hydroxy-1-[4-(2-trifluoromethyl-benzylox...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113028((2R,4S)-4-Hydroxy-1-[4-(2-methyl-benzyloxy)-benzen...)
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113035((2R,4S)-1-[4-(4-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113046((2R,5R)-5-Hydroxy-1-[4-(2-iodo-benzyloxy)-benzenes...)
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113048((2R,5R)-1-(4-Benzyloxy-benzenesulfonyl)-5-hydroxy-...)
Affinity DataIC50: 7nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113044((2R,5R)-5-Hydroxy-1-[4-(2-methyl-benzyloxy)-benzen...)
Affinity DataIC50: 8nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113029((2R,4R)-1-[4-(4-Fluoro-phenoxy)-benzenesulfonyl]-2...)
Affinity DataIC50: 8.5nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113038((2R,4S)-1-(4-Benzyloxy-benzenesulfonyl)-4-hydroxy-...)
Affinity DataIC50: 9nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113034((2R,4S)-1-[4-(3-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113037((2R,5R)-5-Hydroxy-1-[4-(4-trifluoromethyl-benzylox...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113045((2R,5R)-1-[4-(2-Ethyl-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113039((2R,5R)-5-Hydroxy-1-[4-(2-isopropyl-benzyloxy)-ben...)
Affinity DataIC50: 11nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113024((2R,4S)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 14nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113047((2R,4S)-4-Hydroxy-1-[4-(2-methoxy-benzyloxy)-benze...)
Affinity DataIC50: 14nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113021((2R,4S)-1-[4-(3-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50: 15nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113033((2R,5R)-5-Hydroxy-1-[4-(3-trifluoromethyl-benzylox...)
Affinity DataIC50: 15nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113027((2R,4S)-4-Hydroxy-1-[4-(2-trifluoromethyl-benzylox...)
Affinity DataIC50: 16nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113025((2R,5R)-5-Hydroxy-1-[4-(naphthalen-1-ylmethoxy)-be...)
Affinity DataIC50: 16nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113023((2R,4S)-4-Hydroxy-1-[4-(3-methyl-benzyloxy)-benzen...)
Affinity DataIC50: 18nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113049((2R,4R)-2-Hydroxycarbamoyl-1-(4-methoxy-benzenesul...)
Affinity DataIC50: 19nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113030((2R,4S)-4-Hydroxy-1-[4-(4-methyl-benzyloxy)-benzen...)
Affinity DataIC50: 20nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113043((2R,4S)-1-[4-(3-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 21nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113042((2R,4S)-1-[4-(4-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50: 25nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113036((2R,4S)-4-Hydroxy-1-[4-(3-methoxy-benzyloxy)-benze...)
Affinity DataIC50: 27nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113022((2R,4S)-1-[4-(2-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 36nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113031((2R,5R)-1-[4-(2-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50: 39nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113026((2R,5R)-1-[4-(3-Cyano-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50: 49nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113032((2R,4S)-1-[4-(2-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 67nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113020((2R,4S)-1-[4-(Biphenyl-2-ylmethoxy)-benzenesulfony...)
Affinity DataIC50: 67nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113029((2R,4R)-1-[4-(4-Fluoro-phenoxy)-benzenesulfonyl]-2...)
Affinity DataIC50: 120nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113046((2R,5R)-5-Hydroxy-1-[4-(2-iodo-benzyloxy)-benzenes...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113045((2R,5R)-1-[4-(2-Ethyl-benzyloxy)-benzenesulfonyl]-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113039((2R,5R)-5-Hydroxy-1-[4-(2-isopropyl-benzyloxy)-ben...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113040((2R,4R)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113025((2R,5R)-5-Hydroxy-1-[4-(naphthalen-1-ylmethoxy)-be...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113047((2R,4S)-4-Hydroxy-1-[4-(2-methoxy-benzyloxy)-benze...)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113044((2R,5R)-5-Hydroxy-1-[4-(2-methyl-benzyloxy)-benzen...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113044((2R,5R)-5-Hydroxy-1-[4-(2-methyl-benzyloxy)-benzen...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113037((2R,5R)-5-Hydroxy-1-[4-(4-trifluoromethyl-benzylox...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113041((2R,5R)-5-Hydroxy-1-[4-(2-trifluoromethyl-benzylox...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113028((2R,4S)-4-Hydroxy-1-[4-(2-methyl-benzyloxy)-benzen...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113033((2R,5R)-5-Hydroxy-1-[4-(3-trifluoromethyl-benzylox...)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113035((2R,4S)-1-[4-(4-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113034((2R,4S)-1-[4-(3-Chloro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113038((2R,4S)-1-(4-Benzyloxy-benzenesulfonyl)-4-hydroxy-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113043((2R,4S)-1-[4-(3-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50113023((2R,4S)-4-Hydroxy-1-[4-(3-methyl-benzyloxy)-benzen...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibitory concentration against Matrix metalloprotease-1 was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113049((2R,4R)-2-Hydroxycarbamoyl-1-(4-methoxy-benzenesul...)
Affinity DataIC50: 9.60E+3nMAssay Description:Inhibitory concentration against recombinant tumor necrosis factor alpha converting enzyme More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50113024((2R,4S)-1-[4-(4-Fluoro-benzyloxy)-benzenesulfonyl]...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of TNF-alpha release was determined in LPS-stimulated human whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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