Compile Data Set for Download or QSAR
Report error Found 172 Enz. Inhib. hit(s) with all data for entry = 50037109
LigandPNGBDBM50109614([4-(2-Ethoxy-ethoxy)-phenyl]-(3-hydroxycarbamoyl-3...)
Affinity DataIC50: 70nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109630((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 70nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109631((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 180nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109610((7-Amino-3-hydroxycarbamoyl-3,4-dihydro-1H-isoquin...)
Affinity DataIC50: 190nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50370191(CHEMBL366478)
Affinity DataIC50: 230nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109635((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 260nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109629((4-Fluoro-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-...)
Affinity DataIC50: 300nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109628((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 370nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109637(4-[Ethoxy-(4-methoxy-phenyl)-phosphinoyl]-3-hydrox...)
Affinity DataIC50: 430nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109634((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 510nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109624((6-Hydroxycarbamoyl-6,7-dihydro-4H-thieno[3,2-c]py...)
Affinity DataIC50: 520nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109616((7-Hydroxycarbamoyl-7,8-dihydro-5H-pyrido[3,4-b]py...)
Affinity DataIC50: 560nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109625((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 660nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109623((4-Amino-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-1...)
Affinity DataIC50: 660nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109613((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 700nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109633((3-Hydroxycarbamoyl-1,3,4,9-tetrahydro-beta-carbol...)
Affinity DataIC50: 800nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109627((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 810nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109632((3-Fluoro-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-...)
Affinity DataIC50: 830nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109640((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 890nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109611((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 910nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109612((2-Fluoro-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-...)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109615((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109622((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109639((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109621([4-(4-Amino-phenoxy)-phenyl]-(3-hydroxycarbamoyl-3...)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109636((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 1.89E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109626(Biphenyl-4-yl-(3-hydroxycarbamoyl-3,4-dihydro-1H-i...)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109620((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109638((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109618((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 3.11E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109617((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataIC50: 3.56E+3nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50370190(CHEMBL174014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109619((2-Hydroxycarbamoyl-pyrrolidin-1-yl)-(4-methoxy-ph...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50370190(CHEMBL174014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50370192(CHEMBL418655)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of the heparin binding epidermal growth factor (HB-EGF) release from fibrosarcoma HT1080 transfectants expressing alkaline phosphate (AP) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109635((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  0.0800nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109621([4-(4-Amino-phenoxy)-phenyl]-(3-hydroxycarbamoyl-3...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109626(Biphenyl-4-yl-(3-hydroxycarbamoyl-3,4-dihydro-1H-i...)
Affinity DataKi:  0.310nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109621([4-(4-Amino-phenoxy)-phenyl]-(3-hydroxycarbamoyl-3...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109635((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  0.530nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109625((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109629((4-Fluoro-phenyl)-(3-hydroxycarbamoyl-3,4-dihydro-...)
Affinity DataKi:  0.970nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP-1)(recombinant human collagenase-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109633((3-Hydroxycarbamoyl-1,3,4,9-tetrahydro-beta-carbol...)
Affinity DataKi:  1.13nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109635((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  1.81nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP-1)(recombinant human collagenase-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109633((3-Hydroxycarbamoyl-1,3,4,9-tetrahydro-beta-carbol...)
Affinity DataKi:  2.02nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP-1)(recombinant human collagenase-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109630((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  2.03nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)(gelatinase-B).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109633((3-Hydroxycarbamoyl-1,3,4,9-tetrahydro-beta-carbol...)
Affinity DataKi:  2.04nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50109633((3-Hydroxycarbamoyl-1,3,4,9-tetrahydro-beta-carbol...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE) from human acute monocytic leukemia cell line.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109622((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  2.43nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Nippon Organon K.K.

Curated by ChEMBL
LigandPNGBDBM50109630((3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-y...)
Affinity DataKi:  2.95nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP-3)(stromelysin-1).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
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