Compile Data Set for Download or QSAR
Report error Found 74 Enz. Inhib. hit(s) with all data for entry = 50011067
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)
Affinity DataIC50: 0.100nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101925(16-benzyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazape...)
Affinity DataIC50: 0.470nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101923(16-ethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapen...)
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101911(16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazape...)
Affinity DataIC50: 1.30nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101916(17-oxo-16-(3-pyridylmethyl)-(16R)-2-oxa-9,11,15,18...)
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101918(17-oxo-16-(2-thienylmethyl)-(16R)-2-oxa-9,11,15,18...)
Affinity DataIC50: 2.10nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101917(20-oxo-2-oxa-9,11,15,19-tetraazapentacyclo[19.6.2....)
Affinity DataIC50: 2.30nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101910(15,20-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[19...)
Affinity DataIC50: 2.5nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101924(15-benzyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50: 2.60nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101922(16-benzyl-15-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-...)
Affinity DataIC50: 2.70nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101915(17-methyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetra...)
Affinity DataIC50: 3.30nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM14009((5S)-30-oxo-19-oxa-2,6,10,12-tetraazahexacyclo[18....)
Affinity DataIC50: 3.5nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101928(17-benzyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetra...)
Affinity DataIC50: 3.5nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101908(15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18...)
Affinity DataIC50: 3.80nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101926(17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2....)
Affinity DataIC50: 4.30nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101912(19-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[18.6.2....)
Affinity DataIC50: 4.5nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101914(15-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50: 5.70nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101921(19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapen...)
Affinity DataIC50: 6.60nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101931(15,16-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetra...)
Affinity DataIC50: 7nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101912(19-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[18.6.2....)
Affinity DataIC50: 7.10nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101909(15,18-dimethyl-17-oxo-2-oxa-9,11,15,18-tetraazapen...)
Affinity DataIC50: 8.40nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101930(16-methyl-17-oxo-(16S)-2-oxa-9,11,15,18-tetraazape...)
Affinity DataIC50: 11nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101909(15,18-dimethyl-17-oxo-2-oxa-9,11,15,18-tetraazapen...)
Affinity DataIC50: 13nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101932(15,16,18-trimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-t...)
Affinity DataIC50: 14nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101913(18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50: 15nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101932(15,16,18-trimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-t...)
Affinity DataIC50: 15nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101927(16,18-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetra...)
Affinity DataIC50: 16nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101925(16-benzyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazape...)
Affinity DataIC50: 17nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101927(16,18-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetra...)
Affinity DataIC50: 17nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101920(15-benzyl-16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-...)
Affinity DataIC50: 18nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101911(16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazape...)
Affinity DataIC50: 23nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101928(17-benzyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetra...)
Affinity DataIC50: 29nMAssay Description:In vitro inhibitory activity to reduce the human geranylgeranyl transferase type I (GGPTase-1)-catalyzed incorporation of 3H GGPP (100 nM) into K-Ras...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101924(15-benzyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50: 30nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101926(17-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[17.6.2....)
Affinity DataIC50: 37nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101918(17-oxo-16-(2-thienylmethyl)-(16R)-2-oxa-9,11,15,18...)
Affinity DataIC50: 43nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101915(17-methyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetra...)
Affinity DataIC50: 50nMAssay Description:In vitro inhibitory activity to reduce the human geranylgeranyl transferase type I (GGPTase-1)-catalyzed incorporation of 3H GGPP (100 nM) into K-Ras...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101919(15,16-dibenzyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetra...)
Affinity DataIC50: 50nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101913(18-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50: 55nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101921(19-methyl-15,18-dioxo-2-oxa-9,11,16,19-tetraazapen...)
Affinity DataIC50: 65nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101925(16-benzyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazape...)
Affinity DataIC50: 66nMAssay Description:In vitro inhibitory activity to reduce the human geranylgeranyl transferase type I (GGPTase-1)-catalyzed incorporation of 3H GGPP (100 nM) into K-Ras...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101908(15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18...)
Affinity DataIC50: 67nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101918(17-oxo-16-(2-thienylmethyl)-(16R)-2-oxa-9,11,15,18...)
Affinity DataIC50: 72nMAssay Description:In vitro inhibitory activity to reduce the human geranylgeranyl transferase type I (GGPTase-1)-catalyzed incorporation of 3H GGPP (100 nM) into K-Ras...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101912(19-oxo-2-oxa-9,11,15,18-tetraazapentacyclo[18.6.2....)
Affinity DataIC50: 77nMAssay Description:In vitro inhibitory activity to reduce the human geranylgeranyl transferase type I (GGPTase-1)-catalyzed incorporation of 3H GGPP (100 nM) into K-Ras...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101917(20-oxo-2-oxa-9,11,15,19-tetraazapentacyclo[19.6.2....)
Affinity DataIC50: 99nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101931(15,16-dimethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetra...)
Affinity DataIC50: 100nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101916(17-oxo-16-(3-pyridylmethyl)-(16R)-2-oxa-9,11,15,18...)
Affinity DataIC50: 147nMAssay Description:In vitro inhibitory activity to reduce the human geranylgeranyl transferase type I (GGPTase-1)-catalyzed incorporation of 3H GGPP (100 nM) into K-Ras...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101908(15,18-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[18...)
Affinity DataIC50: 150nMAssay Description:In vitro inhibitory activity to reduce the human geranylgeranyl transferase type I (GGPTase-1)-catalyzed incorporation of 3H GGPP (100 nM) into K-Ras...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101922(16-benzyl-15-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-...)
Affinity DataIC50: 184nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101914(15-methyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)
Affinity DataIC50: 196nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101920(15-benzyl-16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-...)
Affinity DataIC50: 240nMAssay Description:In vitro ability to displace radiolabeled FTI from farnesyltransferase in cultured Ha-ras transformed RAT1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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