Compile Data Set for Download or QSAR
Report error Found 20 Enz. Inhib. hit(s) with all data for entry = 50036931
LigandPNGBDBM50099576(1-(4-Imidazol-1-yl-benzoyl)-cyclobutanecarbothioic...)
Affinity DataKd:  8.50E+3nMAssay Description:Inhibition of SUR2B/Kir6.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50030522(CHEMBL554816 | CHEMBL55791 | [1-Benzyl-7-chloro-1H...)
Affinity DataEC50:  1.00E+3nMAssay Description:In vitro immunosuppression in stimulated T cells expressing Voltage-gated potassium channel subunit Kv1.3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50099576(1-(4-Imidazol-1-yl-benzoyl)-cyclobutanecarbothioic...)
Affinity DataKd:  5.20E+3nMAssay Description:Inhibition of SUR2B/Kir6.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50092131(CHEMBL612120 | UCL-1848 | CHEMBL420873 | 1,7-diazo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of hSK1 calcium activated potassium channel (SKCa channel); Range is 1-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50061977(CHEMBL117908 | 17,25-diazonia-2,9-diazaheptacyclo[...)
Affinity DataIC50: 3nMAssay Description:Inhibition of hSK1 calcium activated potassium channel (SKCa channel)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50099566(2-(4-Fluoro-phenyl)-2-(2-fluoro-phenyl)-2-phenyl-a...)
Affinity DataIC50: 9nMAssay Description:Selectivity for gardos channel; (Gardos channel vs 2000 nM for the cardiac IKs channel).)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataIC50: 14nMAssay Description:Inhibition of hERG currents Kv11.1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099583(5-isopropenyloxy-1b,3a,10b-trimethyl-2,3-di(methyl...)
Affinity DataIC50: 86nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.3 transfected CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099581(N-[3-(4-Ethyl-benzenesulfonylamino)-2-hydroxy-inda...)
Affinity DataIC50: 100nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099582(N-[(3R,4S)-3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluo...)
Affinity DataIC50: 120nMAssay Description:Inhibition of IKs currents in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099574(2-(3,4-dimethylphenyl)-3-(4-methoxyphenethyl)thiaz...)
Affinity DataIC50: 200nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50012957(1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfon...)
Affinity DataIC50: 220nMAssay Description:Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099574(2-(3,4-dimethylphenyl)-3-(4-methoxyphenethyl)thiaz...)
Affinity DataIC50: 900nMAssay Description:The inhibitory concentration for 50% was measured on cation fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50083518(4'-Chloro-4-((E)-4-phenyl-but-1-enyl)-biphenyl-2-c...)
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro immunosuppression in stimulated T cells expressing Voltage-gated potassium channel subunit Kv1.3; Range is 1-10More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily D member 3(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099567(Ethanesulfonic acid (6-cyano-3-hydroxy-2,2-dimethy...)
Affinity DataIC50: 1.40E+3nMAssay Description:The inhibitory concentration for 50% was measured on potassium channel complexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily E/KQT member 1(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50099566(2-(4-Fluoro-phenyl)-2-(2-fluoro-phenyl)-2-phenyl-a...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Iks current KvLQT1 potassium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50001786(1-[2-[4-[5-chloro-1-(4-fluorophenyl)-indol-3-yl]-1...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of voltage-gated potassium channel subunit Kv1.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50099573(5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-methoxy...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human SUR2A/Kir6.2 expressed in Xenopus oocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
LigandPNGBDBM50099573(5-[2-(5-chloro-2-methoxybenzamido)ethyl]-2-methoxy...)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of human SUR1/Kir6.2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed