Compile Data Set for Download or QSAR
Report error Found 14 Enz. Inhib. hit(s) with all data for entry = 50010713
TargetSodium/hydrogen exchanger 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50097898(N-(5-Cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-car...)
Affinity DataIC50: 59nMAssay Description:In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50058715(CHEMBL64360 | EMD-96785 | N-(diaminomethylene)-2-m...)
Affinity DataIC50: 140nMAssay Description:In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50097896(N-(5-Cyclopropyl-1-naphthalen-1-yl-1H-pyrazole-4-c...)
Affinity DataIC50: 160nMAssay Description:In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50097895(N-(5-Cyclopropyl-1-phenyl-1H-pyrazole-4-carbonyl)-...)
Affinity DataIC50: 350nMAssay Description:In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | N-(diaminomethylene)-4-isopropyl-3-...)
Affinity DataIC50: 560nMAssay Description:In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50097897(N-(5-Methyl-1-phenyl-1H-pyrazole-4-carbonyl)-guani...)
Affinity DataIC50: 830nMAssay Description:In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50097899(N-(5-Methyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl...)
Affinity DataIC50: 860nMAssay Description:In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50097897(N-(5-Methyl-1-phenyl-1H-pyrazole-4-carbonyl)-guani...)
Affinity DataIC50: 3.90E+3nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50058715(CHEMBL64360 | EMD-96785 | N-(diaminomethylene)-2-m...)
Affinity DataIC50: 9.20E+3nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50097898(N-(5-Cyclopropyl-1-quinolin-5-yl-1H-pyrazole-4-car...)
Affinity DataIC50: 1.20E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50097895(N-(5-Cyclopropyl-1-phenyl-1H-pyrazole-4-carbonyl)-...)
Affinity DataIC50: 1.28E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50097896(N-(5-Cyclopropyl-1-naphthalen-1-yl-1H-pyrazole-4-c...)
Affinity DataIC50: 1.63E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50058759(CHEMBL436559 | N-(diaminomethylene)-4-isopropyl-3-...)
Affinity DataIC50: 2.87E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium/hydrogen exchanger 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50097899(N-(5-Methyl-1-quinolin-5-yl-1H-pyrazole-4-carbonyl...)
Affinity DataIC50: 4.16E+5nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed