Compile Data Set for Download or QSAR
Report error Found 12 Enz. Inhib. hit(s) with all data for entry = 1440
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11459(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11460(2-N-(4-aminocyclohexyl)-6-N-benzyl-9-cyclopentyl-9...)
Affinity DataIC50: 48nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11458(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 50nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11460(2-N-(4-aminocyclohexyl)-6-N-benzyl-9-cyclopentyl-9...)
Affinity DataIC50: 52nMpH: 8.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 0.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11459(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 70nMpH: 8.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 0.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11458(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 226nMpH: 8.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 0.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11461(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 720nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11459(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 780nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11458(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11461(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 2.00E+3nMpH: 8.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 0.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11460(2-N-(4-aminocyclohexyl)-6-N-benzyl-9-cyclopentyl-9...)
Affinity DataIC50: 3.60E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Lawrence Berkeley National Laboratory

LigandPNGBDBM11461(2,6,9-trisubstituted adenine derivative | 2-N-(4-a...)
Affinity DataIC50: 8.80E+3nMpH: 7.5 T: 2°CAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 10 uM ATP/[gamma-33P] ATP, and capturing the 33-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2006
Entry Details Article
PubMed