Compile Data Set for Download or QSAR
Report error Found 19 Enz. Inhib. hit(s) with all data for entry = 50010074
TargetAlpha-1A adrenergic receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi:  0.170nMAssay Description:Binding affinity towards Alpha1A human adrenergic receptors, using [125I]-HEAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi:  0.230nMAssay Description:Binding affinity towards Alpha1A dog adrenergic receptors, using [125I]HEAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi:  0.360nMAssay Description:Binding affinity towards Alpha1A rat adrenergic receptors, using [125I]HEAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi: >45nMAssay Description:Binding affinity towards human alpha-2B-adrenergic receptor, using [3H]rauwolscine as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi: >45nMAssay Description:Binding affinity towards human alpha-2C-adrenergic receptor, using [3H]rauwolscine as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi: >45nMAssay Description:Binding affinity towards human alpha-2A-adrenergic receptor, using [3H]rauwolscine as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi:  54nMAssay Description:Binding affinity towards Histamine H1 receptor in human brain tissue preparation, using [3H]rauwolscine as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi:  62nMAssay Description:Binding affinity towards Alpha1D rat adrenergic receptors, using [125I]HEAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Rat)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi:  79nMAssay Description:Binding affinity towards Alpha1B rat adrenergic receptors, using [125I]HEAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi:  119nMAssay Description:Binding affinity towards Alpha1B human adrenergic receptors, using [125I]HEAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi:  121nMAssay Description:Binding affinity towards Alpha1B dog adrenergic receptors, using [125I]HEAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi:  122nMAssay Description:Binding affinity towards Alpha1D human adrenergic receptors, using [125I]HEAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi:  133nMAssay Description:Binding affinity towards Alpha1D dog adrenergic receptors, using [125I]-HEAT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi: >500nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor using [3H]5-HT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi: >500nMAssay Description:Binding affinity towards 5-HT1D receptor, using [3H]5-HT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Mouse)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi: >500nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor receptor, using [3H]5-HT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi: >500nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of [3H]nitrendipine binding to rat L-type Ca-channel receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50090647(4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxazolidine...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity towards human Histamine H2 receptor, using [3H]tiotidine as radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed