Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with all data for entry = 50036725
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077547(1-{4-[3-(3-Fluoro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataEC50:  2.5nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077557(1-{4-[3-(4-Fluoro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataEC50:  4.5nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077559(1-{4-[3-(3-Fluoro-phenyl)-prop-2-ynyloxy]-[1,2,5]t...)
Affinity DataEC50:  4.90nMAssay Description:Compound was tested for its ability to stimulate phosphoinositol (PI) hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acety...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077554(1-{4-[3-(3,5-Difluoro-phenyl)-prop-2-ynylsulfanyl]...)
Affinity DataEC50:  7.60nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077562(1-{4-[3-(3-Chloro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataEC50:  9nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077548(1-{4-[3-(4-Fluoro-phenyl)-prop-2-ynyloxy]-[1,2,5]t...)
Affinity DataIC50: 10nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077551(1-{4-[3-(3-Chloro-phenyl)-prop-2-ynyloxy]-[1,2,5]t...)
Affinity DataEC50:  11nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50072215(3-(3-((4-phenylbutyl)oxy)-1,2,5-thiadiazol-4-yl)-1...)
Affinity DataIC50: 14nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50072233(1-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3...)
Affinity DataIC50: 16nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50003359(CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...)
Affinity DataIC50: 16nMAssay Description:In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077550(1-{4-[3-(3,5-Difluoro-phenyl)-prop-2-ynyloxy]-[1,2...)
Affinity DataEC50:  20nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077557(1-{4-[3-(4-Fluoro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataIC50: 20nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077559(1-{4-[3-(3-Fluoro-phenyl)-prop-2-ynyloxy]-[1,2,5]t...)
Affinity DataIC50: 21nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077547(1-{4-[3-(3-Fluoro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataIC50: 26nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077558(1-[4-(3-Phenyl-prop-2-ynylsulfanyl)-[1,2,5]thiadia...)
Affinity DataIC50: 27nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077554(1-{4-[3-(3,5-Difluoro-phenyl)-prop-2-ynylsulfanyl]...)
Affinity DataIC50: 28nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077550(1-{4-[3-(3,5-Difluoro-phenyl)-prop-2-ynyloxy]-[1,2...)
Affinity DataIC50: 30nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50004656((2-Hydroxyethyl)trimethyl ammonium chloride carbam...)
Affinity DataIC50: 34nMAssay Description:In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077552(1-{4-[3-(3-Chloro-5-fluoro-phenyl)-prop-2-ynylsulf...)
Affinity DataEC50:  46nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077551(1-{4-[3-(3-Chloro-phenyl)-prop-2-ynyloxy]-[1,2,5]t...)
Affinity DataIC50: 47nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077562(1-{4-[3-(3-Chloro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataIC50: 49nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077558(1-[4-(3-Phenyl-prop-2-ynylsulfanyl)-[1,2,5]thiadia...)
Affinity DataEC50:  62nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077549(1-{4-[3-(4-Chloro-phenyl)-prop-2-ynyloxy]-[1,2,5]t...)
Affinity DataIC50: 63nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50072233(1-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3...)
Affinity DataEC50:  71nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077548(1-{4-[3-(4-Fluoro-phenyl)-prop-2-ynyloxy]-[1,2,5]t...)
Affinity DataEC50:  71nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077561(1-{4-[3-(4-Chloro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataEC50:  80nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077557(1-{4-[3-(4-Fluoro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataEC50:  83nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077556(1-{4-[3-(3-Chloro-5-fluoro-phenyl)-prop-2-ynyloxy]...)
Affinity DataIC50: 92nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077561(1-{4-[3-(4-Chloro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataEC50:  107nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077556(1-{4-[3-(3-Chloro-5-fluoro-phenyl)-prop-2-ynyloxy]...)
Affinity DataEC50:  110nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50072215(3-(3-((4-phenylbutyl)oxy)-1,2,5-thiadiazol-4-yl)-1...)
Affinity DataEC50:  111nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50003359(CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...)
Affinity DataEC50:  135nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077552(1-{4-[3-(3-Chloro-5-fluoro-phenyl)-prop-2-ynylsulf...)
Affinity DataIC50: 142nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50065223(1-Aza-bicyclo[2.2.1]heptan-3-one O-[3-(3-methoxy-p...)
Affinity DataIC50: 150nMAssay Description:In vitro Muscarinic acetylcholine receptor M2 binding was evaluated in rat brain membranes by using [3H]- Oxo-MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50072215(3-(3-((4-phenylbutyl)oxy)-1,2,5-thiadiazol-4-yl)-1...)
Affinity DataEC50:  241nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077561(1-{4-[3-(4-Chloro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataIC50: 242nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50003359(CHEMBL73149 | LY 246708 | CHEMBL21536 | 5-(4-Hexyl...)
Affinity DataEC50:  398nMAssay Description:Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077553(1-{4-[3-(3,5-Dichloro-phenyl)-prop-2-ynylsulfanyl]...)
Affinity DataEC50:  528nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077562(1-{4-[3-(3-Chloro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataEC50:  673nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077559(1-{4-[3-(3-Fluoro-phenyl)-prop-2-ynyloxy]-[1,2,5]t...)
Affinity DataEC50:  683nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50004656((2-Hydroxyethyl)trimethyl ammonium chloride carbam...)
Affinity DataEC50:  700nMAssay Description:Compound was tested for its potency towards Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077552(1-{4-[3-(3-Chloro-5-fluoro-phenyl)-prop-2-ynylsulf...)
Affinity DataEC50:  763nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50072233(1-[4-(3-Phenyl-prop-2-ynyloxy)-[1,2,5]thiadiazol-3...)
Affinity DataEC50:  779nMAssay Description:Compound was tested for its potency at Muscarinic acetylcholine receptor M2 by inhibiting forskolin induced c-AMP formation in CHO-M2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Rat)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077553(1-{4-[3-(3,5-Dichloro-phenyl)-prop-2-ynylsulfanyl]...)
Affinity DataIC50: 788nMAssay Description:Inhibition of [3H]- Oxo-M binding at Muscarinic acetylcholine receptor M2 in rat brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077548(1-{4-[3-(4-Fluoro-phenyl)-prop-2-ynyloxy]-[1,2,5]t...)
Affinity DataEC50:  791nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077558(1-[4-(3-Phenyl-prop-2-ynylsulfanyl)-[1,2,5]thiadia...)
Affinity DataEC50:  853nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077547(1-{4-[3-(3-Fluoro-phenyl)-prop-2-ynylsulfanyl]-[1,...)
Affinity DataEC50:  904nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077555(3-[3-(3,5-Dichloro-phenyl)-prop-2-ynyloxy]-4-tricy...)
Affinity DataEC50:  1.20E+3nMAssay Description:Stimulation of phosphoinositol hydrolysis in the mouse fibroblast cell line A9L-M1 expressing Muscarinic acetylcholine receptor M1.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077549(1-{4-[3-(4-Chloro-phenyl)-prop-2-ynyloxy]-[1,2,5]t...)
Affinity DataEC50:  1.21E+3nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M2(Human)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50077556(1-{4-[3-(3-Chloro-5-fluoro-phenyl)-prop-2-ynyloxy]...)
Affinity DataEC50:  1.48E+3nMAssay Description:Compound was tested for its potency at M-2 receptor by inhibiting forskolin induced c-AMP formation in CHO-M2 cells human M2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2012
Entry Details Article
PubMed
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