Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

LigandChemical structure of BindingDB Monomer ID 26570BDBM26570((3R,4R)-4-N-[4-({2-cyclopropylimidazo[1,2-a]pyridi...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 26570BDBM26570((3R,4R)-4-N-[4-({2-cyclopropylimidazo[1,2-a]pyridi...)
Affinity DataKi:  540nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 26570BDBM26570((3R,4R)-4-N-[4-({2-cyclopropylimidazo[1,2-a]pyridi...)
Affinity DataKi: >3.33E+3nM ΔG°: >-31.3kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 26570BDBM26570((3R,4R)-4-N-[4-({2-cyclopropylimidazo[1,2-a]pyridi...)
Affinity DataKi: >4.50E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed
TargetMatrilysin(Human)
Bristol-Myers Squibb

LigandChemical structure of BindingDB Monomer ID 26570BDBM26570((3R,4R)-4-N-[4-({2-cyclopropylimidazo[1,2-a]pyridi...)
Affinity DataKi: >6.37E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/26/2009
Entry Details Article
PubMed