Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataEC50:  11nMAssay Description:Partial agonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  18nMAssay Description:Antagonist activity at human beta1 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  60nMpH: 7.4 T: 2°CAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetBeta-1 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  81nMAssay Description:Displacement of [3H]-CGP12177 from human beta1 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  661nMAssay Description:Antagonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataEC50:  708nMAssay Description:Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  851nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetBeta-2 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  1.74E+3nMAssay Description:Displacement of [3H]-CGP12177 from human beta2 adrenoceptor expressed in CHOK1 cells after 2 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  2.00E+4nMAssay Description:Antagonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as inhibition of cimaterol-induced [3H]cAMP accumulation incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataKd:  3.55E+4nMAssay Description:The whole cell-binding studies were undertaken in CHO cell lines stably expressing each beta-adrenoceptor subtype. Nonspecific binding was determined...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed
TargetBeta-3 adrenergic receptor(Human)
University of Nottingham

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 25750BDBM25750(N-(2-{[(2R)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]a...)
Affinity DataEC50:  1.00E+5nMAssay Description:Agonist activity at human beta3 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed