Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 4 hits in this display   

TargetCytochrome P450 2A6(Human)
University of Eastern Finland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342656BDBM50342656(benzo[b]thiophen-2-ylmethanamine | CHEMBL1770735)
Affinity DataKi:  10nMAssay Description:Inhibition of human CYP2A6 in baculovirus-infected insect cell system using coumarin 7 as substrate preincubated for 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2016
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
University of Eastern Finland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342656BDBM50342656(benzo[b]thiophen-2-ylmethanamine | CHEMBL1770735)
Affinity DataIC50: 100nMAssay Description:Inhibition of CYP2A6 in human liver microsomes assessed as inhibition of coumarin 7-hydroxylation after 10 mins by plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2A6(Human)
University of Eastern Finland

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342656BDBM50342656(benzo[b]thiophen-2-ylmethanamine | CHEMBL1770735)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP2A6 in baculovirus-infected insect cell system using coumarin 7 as substrate preincubated for 10 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2016
Entry Details Article
PubMed
TargetAcid-sensing ion channel 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50342656BDBM50342656(benzo[b]thiophen-2-ylmethanamine | CHEMBL1770735)
Affinity DataIC50: 9.70E+4nMAssay Description:Inhibition of human ASIC3 expressed in HEK293 cells assessed as inhibition of acid-evoked current by manual patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed