Compile Data Set for Download or QSAR
Report error Found 3168 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4D'
LigandPNGBDBM14361(Adeo | 4-(3-cyclopentyloxy-4-methoxy-phenyl)pyrrol...)
Affinity DataEC50:  1.10E+3nMAssay Description:cAMP elevation in U937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50176377((R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)...)
Affinity DataEC50:  22nMAssay Description:cAMP elevation in U937 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50310204(7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...)
Affinity DataEC50:  6.69E+4nMAssay Description:Inhibition of human PDE4D in U937 cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50310217(7-(3'-Cyclopropylmethoxy-4'-difluoromethoxyphenyl)...)
Affinity DataEC50:  1.61E+3nMAssay Description:Inhibition of human PDE4D in U937 cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2010
Entry Details Article
PubMed
LigandPNGBDBM50310364(CHEMBL1077126 | YESSOTOXIN)
Affinity DataKd:  1.00E+3nMAssay Description:Binding affinity to recombinant PDE4D by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
LigandPNGBDBM50310365(desulfated yessotoxin | CHEMBL1077121)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to recombinant PDE4D by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
LigandPNGBDBM50310366(Brevetoxin | CHEMBL1077122)
Affinity DataKd:  3.80E+3nMAssay Description:Binding affinity to recombinant PDE4D by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
LigandPNGBDBM50310367((2R,3S,5R,6S)-5-(benzyloxy)-6-(2-(benzyloxy)ethyl)...)
Affinity DataKd:  8.00E+4nMAssay Description:Binding affinity to recombinant PDE4D by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
LigandPNGBDBM50310368((2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,13aS)-8-(2-Hydr...)
Affinity DataKd:  2.90E+4nMAssay Description:Binding affinity to recombinant PDE4D by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
LigandPNGBDBM50310369((2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,13aS)-9-Benzylo...)
Affinity DataKd:  1.10E+4nMAssay Description:Binding affinity to recombinant PDE4D by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
LigandPNGBDBM50246052((1S,3R,5S,7R,9S,10R,12S,14R,17S,19R,21S,23R,25S,26...)
Affinity DataKd:  4.80E+3nMAssay Description:Binding affinity to recombinant PDE4D by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2010
Entry Details Article
PubMed
LigandPNGBDBM50474146(CHEMBL1160098)
Affinity DataEC50:  2.35E+4nMAssay Description:Activation of PDE4D3 (phosphodiesterase).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50474147(CHEMBL1160097)
Affinity DataEC50:  2.42E+4nMAssay Description:Activation of PDE4D3 (phosphodiesterase).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50474148(CHEMBL1160096)
Affinity DataEC50:  2.35E+4nMAssay Description:Activation of PDE4D3 (phosphodiesterase).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50516235(CHEMBL4563408)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human recombinant PDE4D2 using [3H]cAMP as substrate measured after 20 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50512766(CHEMBL4436770)
Affinity DataKd:  79nMAssay Description:Binding affinity to human PDE4D assessed as dissociation constant treated for 320 secs measured for 900 secs by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50512753(CHEMBL4463356)
Affinity DataKd:  251nMAssay Description:Binding affinity to human PDE4D assessed as dissociation constant treated for 60 secs measured for 300 secs by SPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50630971(CHEMBL5407478)
Affinity DataEC50:  1.20E+3nMAssay Description:Activation of PDE4D5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
PubMed
LigandPNGBDBM50017294(CHEMBL3288029)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human PDE4D using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50017295(CHEMBL3288030)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human PDE4D using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human PDE4D by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50183792(1-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50183794(3-isopropyl-1-(4-(methylsulfonyl)phenyl)-1-((3-(6-...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50183803(N-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50183805(1-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50353703(CHEMBL1830646)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.130nMAssay Description:Inhibition of human recombinant PDE4D using [3H]cAMP as substrate preincubated with enzyme for 10 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50174025(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)
Affinity DataIC50: 0.190nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50325788(2-(4-((8-(3-(difluoromethoxy)phenyl)quinolin-6-yl)...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50174030((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.270nMAssay Description:Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50183791(isopropyl (3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50183808(N-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human GST-PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50304417(CHEMBL593656 | cis-(+/-)-4-(3,4-Dimethoxyphenyl)-2...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50347344(CHEMBL1801156)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50017340(CHEMBL3113734)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of PDE4D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
LigandPNGBDBM14359(3-[(2S)-2-[3-cyclopropoxy-4-(difluoromethoxy)pheny...)
Affinity DataIC50: 0.400nMpH: 7.5 T: 2°CAssay Description:PDE4 catalytic activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using PDE-SPA kit (Amersham International). [3H]-AMP was c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2007
Entry Details Article
PubMed
LigandPNGBDBM50304410(cis-2-[(E)-4-(1H-Imidazol-1-yl)but-2-enyl]-4-(3,4-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human recombinant PDE4D catalytic domain cloned from human HL60 cells assessed as inhibition of cAMP hydrolysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
LigandPNGBDBM50325790(methyl 2-(4-((8-(3-methoxyphenyl)quinolin-6-yl)met...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
LigandPNGBDBM50353700(CHEMBL1830643)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human PDE4D3 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50174020(L-869298 | (S)-(+)-3-{2-[(3-Cyclopropyloxy-4-diflu...)
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2012
Entry Details Article
PubMed
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PDE4D (unknown origin) using cAMP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM14774(DAXAS | 3-(cyclopropylmethoxy)-N-(3,5-dichloropyri...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PDE4D2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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