Compile Data Set for Download or QSAR
Report error Found 3902 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415001(GSK-256066 | CHEMBL570015 | GSK-256066 (3))
Affinity DataIC50: 0.00794nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50559714(CHEMBL4794267)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of recombinant human PDE4B2 preincubated for 30 mins followed by [3H]cyclic AMP addition and measured after 20 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415001(GSK-256066 | CHEMBL570015 | GSK-256066 (3))
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50559706(CHEMBL4744560)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of recombinant human PDE4B2 using cAMP as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017300(CHEMBL3287987)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414999(CHEMBL569791)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50199699(CHEMBL3986586)
Affinity DataIC50: 0.0140nMAssay Description:Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydrolysis to [3H]AMP incubated for 60 mins by PDE-SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017308(CHEMBL3287995)
Affinity DataIC50: 0.0158nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017304(CHEMBL3287991)
Affinity DataIC50: 0.0158nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017296(CHEMBL3287739)
Affinity DataIC50: 0.0158nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017295(CHEMBL3288030)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017307(CHEMBL3287994)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017303(CHEMBL3287990)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50017294(CHEMBL3288029)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of rat PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017338(CHEMBL3288027)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017335(CHEMBL3288024)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017313(CHEMBL3287999)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50353707(CHEMBL1830791)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human PDE4B1 assessed as inhibition of [3H]cAMP hydrolysis to [3H]AMP after 15 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50415009(CHEMBL571381)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of human recombinant PDE4B by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017298(CHEMBL3288010)
Affinity DataIC50: 0.0251nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017294(CHEMBL3288029)
Affinity DataIC50: 0.0251nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017324(CHEMBL3288012)
Affinity DataIC50: 0.0251nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
LigandPNGBDBM50017295(CHEMBL3288030)
Affinity DataIC50: 0.0251nMAssay Description:Inhibition of rat PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017301(CHEMBL3287988)
Affinity DataIC50: 0.0251nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017314(CHEMBL3288000)
Affinity DataIC50: 0.0251nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50246909(CHEMBL4075951)
Affinity DataIC50: 0.0280nMAssay Description:Inhibition of human recombinant PDE4B expressed insect sf9 cells by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2019
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50199728(CHEMBL3919325)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydrolysis to [3H]AMP incubated for 60 mins by PDE-SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50379979(CHEMBL2012227)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50199727(CHEMBL3913876)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydrolysis to [3H]AMP incubated for 60 mins by PDE-SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50183805(1-((3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phenyl)...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human GST-PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50134434(CHEMBL3746046)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human recombinant PDE4B1 expressed in insect Sf9 cells by fluorescence capillary-electrophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50199695(CHEMBL3957127)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydrolysis to [3H]AMP incubated for 60 mins by PDE-SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50199702(CHEMBL3952586)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydrolysis to [3H]AMP incubated for 60 mins by PDE-SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50199701(CHEMBL3968147)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydrolysis to [3H]AMP incubated for 60 mins by PDE-SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017306(CHEMBL3287993)
Affinity DataIC50: 0.0316nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017327(CHEMBL3288016)
Affinity DataIC50: 0.0316nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017336(CHEMBL3288025)
Affinity DataIC50: 0.0316nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017315(CHEMBL3288001)
Affinity DataIC50: 0.0316nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017333(CHEMBL3288022)
Affinity DataIC50: 0.0316nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017302(CHEMBL3287989)
Affinity DataIC50: 0.0316nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017311(CHEMBL3287997)
Affinity DataIC50: 0.0316nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017297(CHEMBL3288009)
Affinity DataIC50: 0.0398nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50017339(CHEMBL3288028)
Affinity DataIC50: 0.0398nMAssay Description:Inhibition of human recombinant PDE4B using [3H]cAMP by packard topcount scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM677013(US11993596, Compound WX024 | US20240294526, Compou...)
Affinity DataIC50: 0.0400nMAssay Description:Procedure:1. The recombinant human PDE4B enzyme and enzyme substrate (1 uM cAMP) were each dissolved in newly prepared experimental buffer solution;2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50199710(CHEMBL3974515)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydrolysis to [3H]AMP incubated for 60 mins by PDE-SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2018
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50199722(CHEMBL3950249)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of human recombinant PDE4B1 assessed as reduction in [3H]cAMP hydrolysis to [3H]AMP incubated for 60 mins by PDE-SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2018
Entry Details Article
PubMed
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.0400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50379984(CHEMBL2012232)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE4BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of human PDE4B by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Displayed 1 to 50 (of 3902 total ) | Next | Last >>
Jump to: