Compile Data Set for Download or QSAR
Report error Found 117 Enz. Inhib. hit(s) with Target = 'UDP-N-acetylmuramate--L-alanine ligase'
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123114((1R,2S)-1-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123118((S)-2-((4-((5-(tert-butyl)-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123125((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 0.5nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123107((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 0.600nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123127((R)-((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-...)
Affinity DataIC50: 0.600nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123123((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 0.700nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123111((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 1nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123124((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 1nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123119((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 1.20nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123124((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 1.30nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123122((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 2nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123114((1R,2S)-1-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 2nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123122((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 3nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123125((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 3nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123117((R)-2-((4-((5-(tert-butyl)-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 4nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123118((S)-2-((4-((5-(tert-butyl)-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 4nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123123((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 4nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123108(((S)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylam...)
Affinity DataIC50: 5nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123111((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 5nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123127((R)-((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-...)
Affinity DataIC50: 5nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123121((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 6nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123113((S)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 7nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123126((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 7nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123105((S)-2-(4-(5-tert-butyl-1H-pyrazol-3-ylamino)-1H-py...)
Affinity DataIC50: 8nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123112((S)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 8nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123115((R)-2-((4-((5-(tert-butyl)-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 8nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123120((R)-2-((4-((5-(tert-butyl)-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 8nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123116((R)-2-((4-((5-(tert-butyl)-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 9nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123104((S)-2-cyclohexyl-2-(4-(5-isopropyl-1H-pyrazol-3-yl...)
Affinity DataIC50: 10nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123106((R)-2-cyclohexyl-2-(4-(3-isopropyl-1H-pyrazol-5-yl...)
Affinity DataIC50: 10nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123109(2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylamino)-...)
Affinity DataIC50: 11nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123112((S)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 11nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123110((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 13nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123119((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 15nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123117((R)-2-((4-((5-(tert-butyl)-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 21nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123115((R)-2-((4-((5-(tert-butyl)-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 40nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM119081(MurC inhibitor (compound 20))
Affinity DataIC50: 49nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123103((S)-2-cyclohexyl-2-(4-(3-cyclopropyl-1H-pyrazol-5-...)
Affinity DataIC50: 50nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123121((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 52nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123120((R)-2-((4-((5-(tert-butyl)-1-methyl-1H-pyrazol-3-y...)
Affinity DataIC50: 57nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123113((S)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 60nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123126((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 60nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123109(2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylamino)-...)
Affinity DataIC50: 101nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM123110((R)-2-(4-(5-tert-butyl-1-methyl-1H-pyrazol-3-ylami...)
Affinity DataIC50: 188nMT: 2°CAssay Description:The reactions (25 μL) were carried out in 25 mM Tris-HCl pH 8.0, 10 mM ammonium sulfate, 1.25 mM DTT, 0.002% Brij-35, 10 mM MgCl2, 40 μM UN...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Astrazeneca India

LigandPNGBDBM123102((1-(4-(3-cyclopropyl-1H-pyrazol-5-ylamino)-1H-pyra...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:The reactions (50 μL) were carried out in 50 mM Tris-HCl pH 8.0, 20 mM ammonium sulfate, 2.5 mM DTT, 0.002% Brij-35, 1 mM MgCl2, 18 μM UNAM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM119083(MurC inhibitor (compound 22))
Affinity DataIC50: 2.30E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2014
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM50475590(CHEMBL370421)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibitory activity against MurC in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM50475601(CHEMBL199812)
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibitory activity against MurC in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM50475579(CHEMBL382202)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibitory activity against MurC in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
TargetUDP-N-acetylmuramate--L-alanine ligase(Escherichia coli (strain K12))
Astrazeneca India

LigandPNGBDBM50475600(CHEMBL381006)
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibitory activity against MurC in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed
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