Compile Data Set for Download or QSAR
Report error Found 40 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK [2-635]'
TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211959(US9290481, 3.1)
Affinity DataIC50: 0.5nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222932(US9315500, 2.2)
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211951(US9290481, 1.2)
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM50076187(CHEMBL3416027 | US9290481, 1.4)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211960(US9290481, 4.2)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222933(US9315500, 2.3)
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222934(US9315500, 2.4)
Affinity DataIC50: 1.30nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222931(US9315500, 2.1)
Affinity DataIC50: 1.60nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222935(US9315500, 2.5)
Affinity DataIC50: 1.60nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222952(US9315500, 3.2)
Affinity DataIC50: 1.80nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222936(US9315500, 2.6)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222953(US9315500, 3.3)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222955(US9315500, 1.1)
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222937(US9315500, 2.7)
Affinity DataIC50: 2.10nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222938(US9315500, 2.8)
Affinity DataIC50: 2.30nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM50076189(CHEMBL3416024 | US9290481, 4.1)
Affinity DataIC50: 2.70nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222939(US9315500, 2.9)
Affinity DataIC50: 2.70nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211952(US9290481, 1.3)
Affinity DataIC50: 3.5nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211958(US9290481, 2.6)
Affinity DataIC50: 4.60nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211954(US9290481, 2.2)
Affinity DataIC50: 5.10nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222940(US9315500, 2.10)
Affinity DataIC50: 5.20nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222941(US9315500, 2.11)
Affinity DataIC50: 5.40nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222943(US9315500, 2.13)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222942(US9315500, 2.12)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222944(US9315500, 2.14)
Affinity DataIC50: 8nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222946(US9315500, 2.16)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222945(US9315500, 2.15)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222951(US9315500, 3.1)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211955(US9290481, 2.3)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211953(US9290481, 2.1)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222947(US9315500, 2.17)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM50076185(CHEMBL3416026 | US9290481, 1.1)
Affinity DataIC50: 23nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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PDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222948(US9315500, 2.18)
Affinity DataIC50: 26nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211957(US9290481, 2.5)
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222954(US9315500, 3.4)
Affinity DataIC50: 32nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222949(US9315500, 2.19)
Affinity DataIC50: 42nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222930(US9315500, 1.2)
Affinity DataIC50: 44nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM222950(US9315500, 2.20)
Affinity DataIC50: 45nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM211956(US9290481, 2.4)
Affinity DataIC50: 86nMpH: 7.5 T: 2°CAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, as well as four 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2017
Entry Details
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TargetTyrosine-protein kinase SYK [2-635](Human)
Novartis

US Patent
LigandPNGBDBM225230(EED226 | US11013745, Compound EED226)
Affinity DataIC50: 1.00E+4nMAssay Description:All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2017
Entry Details Article
PubMed