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Report error Found 556 Enz. Inhib. hit(s) with Target = 'Tyrosinase'
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50322068((-)-N-Formylanonaine | CHEMBL1170090)
Affinity DataEC50:  9.00E+4nMAssay Description:Inhibition of tyrosinase in human HEMn-MP assessed as reduction of melanin level after 2 days by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetTyrosinase(Bacillus megaterium)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50031467(Kojic Acid | CHEMBL287556 | 5-HYDROXY-2-(HYDROXYME...)
Affinity DataKd:  3.77E+5nMAssay Description:Binding affinity to Bacillus megaterium Tyrosinase expressed in Escherichia coli BL21 assessed as dissociation constant incubated for 5 mins by by Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50293593(4-(2-aminothiazol-4-yl)benzene-1,3-diol | CHEMBL54...)
Affinity DataEC50:  51nMAssay Description:Inhibition of human his tagged tyrosinase expressed in HEK293 cells using L-DOPA as substrate incubated for 10 mins by microtitre plate reader analys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50031467(Kojic Acid | CHEMBL287556 | 5-HYDROXY-2-(HYDROXYME...)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50: 0.613nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50241367(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...)
Affinity DataIC50: 0.762nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50217942(3-Rhamnoglucosylquercetin | cid_5280805 | CHEMBL22...)
Affinity DataIC50: 0.856nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50378581(NICOTIFLOROSIDE)
Affinity DataIC50: 0.908nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human his tagged tyrosinase expressed in HEK293 cells using L-DOPA as substrate by HTS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50269559(Norartocarpetin, 5 | CHEMBL463145 | 2-(2,4-dihydro...)
Affinity DataIC50: 23nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-dihydroxyphenylalanine as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2020
Entry Details Article
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50: 30nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50044784(CHEBI:79090 | SB-202190 | US10865384, Compound SB2...)
Affinity DataIC50: 30nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50: 34nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50045333(CHEBI:90705 | SB-203580)
Affinity DataIC50: 34nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50287127((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Affinity DataIC50: 60nMAssay Description:Compound was evaluated for inhibition of tyrosinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50203985(2,2',4,4'-tetrahydroxychalcone | 2,4,2',4'-tetrahy...)
Affinity DataIC50: 70nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50203985(2,2',4,4'-tetrahydroxychalcone | 2,4,2',4'-tetrahy...)
Affinity DataIC50: 70nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50251013(morachalcone A | 2,4,2',4'-tetrahydroxy-3'-prenylc...)
Affinity DataIC50: 80nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50251013(morachalcone A | 2,4,2',4'-tetrahydroxy-3'-prenylc...)
Affinity DataIC50: 80nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50031467(Kojic Acid | CHEMBL287556 | 5-HYDROXY-2-(HYDROXYME...)
Affinity DataIC50: 80nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50230001(4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)...)
Affinity DataIC50: 89nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50230001(4-(4-fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)...)
Affinity DataIC50: 89nMAssay Description:Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50441626(GLABRIDIN | US9783551, Compound 1)
Affinity DataIC50: 90nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2020
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50108046((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cells using L-tyrosine and DOPA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50172095(CHEBI:69084 | Glyasperin D)
Affinity DataIC50: 154nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate assessed as oxidation of L-tyrosine after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50529589(CHEMBL4239110)
Affinity DataIC50: 170nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50529589(CHEMBL4239110)
Affinity DataIC50: 170nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50172096(CHEBI:69089 | Glyasperin C)
Affinity DataIC50: 177nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate assessed as oxidation of L-tyrosine after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2017
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50146416((S)-2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Affinity DataIC50: 240nMAssay Description:Inhibitory activity against mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50193667(2,4,3',5'-tetrahydroxybibenzyl | CHEMBL221291)
Affinity DataIC50: 300nMAssay Description:Inhibition of tyrosinase in mouse B16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50193667(2,4,3',5'-tetrahydroxybibenzyl | CHEMBL221291)
Affinity DataIC50: 300nMAssay Description:Inhibition of tyrosinase in mouse B16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM85807(NSC_6054 | CAS_60-12-8 | Beta-PEA)
Affinity DataIC50: 315nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50146418((S)-2-{(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Affinity DataIC50: 330nMAssay Description:Inhibitory activity against mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50263336(4,4'-(ethane-1,2-diyl)dibenzene-1,3-diol | CHEMBL4...)
Affinity DataIC50: 370nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50146415((S)-2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Affinity DataIC50: 390nMAssay Description:Inhibitory activity against mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50264086((2S,3R,4S,5R)-2-(4-(2,4-dihydroxyphenethyl)-3-hydr...)
Affinity DataIC50: 430nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50292636(4-hexyl resorcinol | CHEMBL443605 | ACRISORCIN)
Affinity DataIC50: 560nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2016
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50608337((+)-Anymol | CHEMBL477832)
Affinity DataIC50: 635nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50340788(4-(beta-D-Cellobiopyranosyl)-2,2',4'-trihydroxybib...)
Affinity DataIC50: 680nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50366430(CHEMBL1794031)
Affinity DataIC50: 700nMAssay Description:Compound was evaluated for inhibition of tyrosinase enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50264087((2S,2'S,3R,3'R,4S,4'S,5R,5'R)-2,2'-(4-(2,4-dihydro...)
Affinity DataIC50: 730nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50237231(CHEMBL4063130)
Affinity DataIC50: 750nMAssay Description:Inhibition of tyrosinase in mouse B16 cells assessed as reduction in melanin production measured after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2019
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50340787(4-(beta-D-Glucopyranosyl)-2,2',4'-trihydroxybibenz...)
Affinity DataIC50: 770nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50146414((2S)-2-[(2S)-2-[(2S)-2-({[(5-hydroxy-4-oxo-4H-pyra...)
Affinity DataIC50: 780nMAssay Description:Inhibitory activity against mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50529600(CHEMBL4445400)
Affinity DataIC50: 800nMAssay Description:Inhibition of tyrosinase in mouse B16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Mouse)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50529600(CHEMBL4445400)
Affinity DataIC50: 800nMAssay Description:Inhibition of tyrosinase in mouse B16 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50340789(2,2',4'-Trihydroxy-4-(beta-D-maltopyranosyl)bibenz...)
Affinity DataIC50: 830nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50: 900nMAssay Description:Inhibition of human His-tagged tyrosinase CD expressed in HEK293 cells assessed as inhibition of melanin production using L-DOPA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50251005((S)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxychroman-4...)
Affinity DataIC50: 980nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosinase(Human)
Kaohsiung Medical University

Curated by ChEMBL
LigandPNGBDBM50251005((S)-2-(2,4-dihydroxyphenyl)-5,7-dihydroxychroman-4...)
Affinity DataIC50: 980nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
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