Compile Data Set for Download or QSAR
Report error Found 774 Enz. Inhib. hit(s) with Target = 'Trypanothione reductase'
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50313985(8-methyl-8-azabicyclo[3.2.1]octan-3-one O-(4-chlor...)
Affinity DataEC50:  3.50E+4nMAssay Description:Inhibition of Trypanosoma cruzi X10/1 recombinant trypanothione reductase assessed as increase in absorbance at 410 nm due to the formation of TNBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetTrypanothione reductase(Leishmania infantum)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50612872(CHEMBL5284653)
Affinity DataKd:  1.00E+3nMAssay Description:Competitive inhibition of HIS-FLAG-tagged recombinant Leishmania infantum TryR expressed in Escherichia coli assessed as dissociation constant by SPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50615386(CHEMBL5283195)
Affinity DataIC50: 200nMAssay Description:Inhibition of Trypanosoma cruzi TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354279(CHEMBL1836603)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50087158(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50: 300nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50201774(3-(dimethylamino)-1-(3-nitrophenyl)propan-1-one hy...)
Affinity DataIC50: 340nMAssay Description:Inhibition of TR by DTNB-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354332(CHEMBL1836574)
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354268(CHEMBL1836570)
Affinity DataIC50: 370nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354265(CHEMBL1836567)
Affinity DataIC50: 420nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50087157(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50: 450nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 uM T(S)2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50087157(5-(8-Hydroxy-3-methyl-1,4-dioxo-1,4-dihydro-naphth...)
Affinity DataIC50: 500nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50070270(Pentanedioic acid bis-[(3-{4-bromo-2-[3-(4-methyl-...)
Affinity DataIC50: 550nMAssay Description:Inhibition of trypanothione reductase from Trypanosoma cruzi, in the presence 57 uM of trypanothione T(SH)2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50070270(Pentanedioic acid bis-[(3-{4-bromo-2-[3-(4-methyl-...)
Affinity DataIC50: 550nMAssay Description:Inhibition of Trypanosoma cruzi TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354290(CHEMBL1836615)
Affinity DataIC50: 590nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50087156(5-{3-[4-(3-Dibutylamino-propylcarbamoyl)-butyl]-8-...)
Affinity DataIC50: 600nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50178811(N-(3-aminopropyl)-4-tert-butyl-N,N-dimethylbenzena...)
Affinity DataIC50: 600nMAssay Description:Inhibitory activity against trypanothione reductase from Trypanosoma cruzi using 0.12 mM TSST substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50615388(CHEMBL5280255)
Affinity DataIC50: 600nMAssay Description:Inhibition of Trypanosoma cruzi TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354287(CHEMBL1836611)
Affinity DataIC50: 710nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354333(CHEMBL1836612)
Affinity DataIC50: 730nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50615401(CHEMBL5081809)
Affinity DataIC50: 750nMAssay Description:Inhibition of Trypanosoma brucei TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354269(CHEMBL1836571)
Affinity DataIC50: 780nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50091160([3-(2-Chloro-phenothiazin-10-yl)-propyl]-(3,4-dich...)
Affinity DataIC50: 780nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354270(CHEMBL1836572)
Affinity DataIC50: 790nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354274(CHEMBL1836577)
Affinity DataIC50: 790nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50096063(6-(5-Hydroxy-3-{5-[3-(4-methyl-piperazin-1-yl)-pro...)
Affinity DataIC50: 800nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 uM T(S)2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50615389(CHEMBL5283514)
Affinity DataIC50: 800nMAssay Description:Inhibition of Trypanosoma cruzi TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354260(CHEMBL1836562)
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354317(CHEMBL1836371)
Affinity DataIC50: 810nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Leishmania infantum)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50278343(CHEMBL4169040)
Affinity DataIC50: 820nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
TargetTrypanothione reductase(Leishmania infantum)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50278343(CHEMBL4169040)
Affinity DataIC50: 820nMAssay Description:Inhibition of oxidoreductase activity of recombinant Leishmania infantum trypanothione reductase pre-incubated for 10 mins before T[S]2 and NADPH add...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2020
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354257(CHEMBL1836559)
Affinity DataIC50: 860nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354281(CHEMBL1836606)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Leishmania infantum)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50267312(CHEMBL4105040)
Affinity DataIC50: 900nMAssay Description:Inhibition of recombinant Leishmania infantum TryR preincubated for 10 mins followed by T[S]2 substrate addition and measured after 1 hr in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2020
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354311(CHEMBL1836365)
Affinity DataIC50: 930nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354299(CHEMBL1836378)
Affinity DataIC50: 930nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50615385(CHEMBL5270809)
Affinity DataIC50: 930nMAssay Description:Inhibition of Trypanosoma cruzi TryRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354314(CHEMBL1836368)
Affinity DataIC50: 940nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50185388(N-(3,3-diphenylpropyl)-1-3-[3-({7-[(3-{N-[3-(3,3-d...)
Affinity DataIC50: 950nMAssay Description:Inhibition of Trypanosoma cruzi TRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50335534(1-(1-benzylpiperidin-4-yl)-3-(pyridin-3-yl)thioure...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as inhibition of thionitrobenzoate formation by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50335534(1-(1-benzylpiperidin-4-yl)-3-(pyridin-3-yl)thioure...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase assessed as inhibition of thionitrobenzoate formation by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2011
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354325(CHEMBL1836380)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50571704(CHEMBL4859269)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Trypanosoma brucei TryR oxidoreductase activity using TS2 as substrate by spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50615383(CHEMBL5273760)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of Trypanosoma cruzi TryR expressed in escherichia coli SG5More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50087155(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50: 1.10E+3nMAssay Description:Concentration required for inhibition of Trypanothione reductase (TcTR) from Trypanosoma cruzi in the presence of 50 uM TS2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354313(CHEMBL1836367)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50096043(5-(3-Methyl-1,4-dioxo-1,4-dihydro-naphthalen-2-yl)...)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione disulfide reductase, assay in presence of 57 uM T(S)2.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354291(CHEMBL1836616)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma brucei brucei)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50354321(CHEMBL1836375)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant trypanothione reductase from Trypanosoma brucei brucei S427 by DTNB-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Trypanosoma cruzi)
Institute of Medical Research

Curated by ChEMBL
LigandPNGBDBM50091163(Benzhydryl-[3-(2-chloro-phenothiazin-10-yl)-propyl...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against Trypanosoma cruzi trypanothione reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetTrypanothione reductase(Leishmania infantum)
Universidad De Alcal£

Curated by ChEMBL
LigandPNGBDBM50267314(CHEMBL4076896)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of recombinant Leishmania infantum TryR preincubated for 10 mins followed by T[S]2 substrate addition and measured after 1 hr in presence ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2020
Entry Details Article
PubMed
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