Compile Data Set for Download or QSAR
Report error Found 6 Enz. Inhib. hit(s) with Target = 'Topoisomerase I'
TargetTopoisomerase I subunit B(Leishmania major)
University of Puerto Rico

Curated by ChEMBL
LigandPNGBDBM50392268(CHEMBL2153501)
Affinity DataEC50:  6.78E+4nMAssay Description:Inhibition of Leishmania donovani topoisomerase 1B-mediated relaxation of supercoiled pSK DNA after 30 mins by ethidium bromide staining based agaros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTopoisomerase I subunit B(Leishmania major)
University of Puerto Rico

Curated by ChEMBL
LigandPNGBDBM50329257(2-Hexadecynoic acid | CHEMBL1269411)
Affinity DataEC50:  2.87E+4nMAssay Description:Inhibition of Leishmania donovani topoisomerase 1B-mediated relaxation of supercoiled pSK DNA after 30 mins by ethidium bromide staining based agaros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTopoisomerase I subunit B(Leishmania major)
University of Puerto Rico

Curated by ChEMBL
LigandPNGBDBM50392269(CHEMBL2153502)
Affinity DataEC50:  5.30E+3nMAssay Description:Inhibition of Leishmania donovani topoisomerase 1B-mediated relaxation of supercoiled pSK DNA after 30 mins by ethidium bromide staining based agaros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTopoisomerase I subunit B(Leishmania major)
University of Puerto Rico

Curated by ChEMBL
LigandPNGBDBM50008923(4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaz...)
Affinity DataEC50:  670nMAssay Description:Inhibition of Leishmania donovani topoisomerase 1B-mediated relaxation of supercoiled pSK DNA after 30 mins by ethidium bromide staining based agaros...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTopoisomerase I(Bovine)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50450080(CHEMBL4176420)
Affinity DataIC50: 14nMAssay Description:Inhibition of calf thymus topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA measured after 30 mins by agarose gel electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTopoisomerase I(Bovine)
Csir-Indian Institute of Chemical Technology

Curated by ChEMBL
LigandPNGBDBM50450081(CHEMBL4159820)
Affinity DataIC50: 14nMAssay Description:Inhibition of calf thymus topoisomerase 1-mediated relaxation of supercoiled pBR322 DNA measured after 30 mins by agarose gel electrophoresis methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed