Compile Data Set for Download or QSAR
Report error Found 273 Enz. Inhib. hit(s) with Target = 'Thermolysin'
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50473782(CHEMBL91805)
Affinity DataKd:  0.0631nMAssay Description:Binding affinity against ThermolysinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50292712(1beta-D-arabinofuranosyl-N4-lauroylcytosine | CHEM...)
Affinity DataIC50: 0.0640nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50474105(CHEMBL43341)
Affinity DataKi:  0.0680nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50006111(CHEMBL44737 | (ZFPLA) 2-[2-(2-Benzyloxycarbonylami...)
Affinity DataKi:  0.0680nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50474138(CHEMBL38873)
Affinity DataKi:  1.51nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50035249(N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-N'-hydroxy...)
Affinity DataIC50: 2nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070927(CHEMBL3409520)
Affinity DataKi:  4.90nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50035246(2-(2-Hydroxycarbamoyl-4-methyl-pentanoylamino)-3-(...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50035247(2-(2-Hydroxycarbamoyl-3-methyl-butyrylamino)-3-(1H...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070925(CHEMBL3409522)
Affinity DataKi:  5.30nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070926(CHEMBL3409521)
Affinity DataKi:  5.5nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070924(CHEMBL3409523)
Affinity DataKi:  5.80nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50044226(1-hydroxy-1-phenylethyl-phosphinoylamino]-propiony...)
Affinity DataIC50: 7nMAssay Description:Inhibition of metallopeptidase thermolysinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50035239(N-[1-Carbamoyl-2-(1H-indol-3-yl)-ethyl]-N'-hydroxy...)
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50006110(CHEMBL416089 | (ZGPLA) 2-[2-(2-Benzyloxycarbonylam...)
Affinity DataKi:  9.10nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50474141(CHEMBL43176)
Affinity DataKi:  9.12nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070937(CHEMBL3409510)
Affinity DataKi:  10nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50121452((S)-2-{(S)-2-[(Benzyloxycarbonylamino-methyl)-hydr...)
Affinity DataKi:  11nMAssay Description:Competitive inhibition of thermolysin evaluated using the substrate FAGLA (Sigma); Competitive binding observedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50474083(CHEMBL41348)
Affinity DataKi:  11nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50321113(3-Phenyl-2-(trifluoromethyl)quinazolin-4(3H)-one |...)
Affinity DataIC50: 11.5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.1 M substrate FaGLaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50321113(3-Phenyl-2-(trifluoromethyl)quinazolin-4(3H)-one |...)
Affinity DataKi:  11.5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 mins by microplate fluorescence analysis in presence of 0.5 to 2 mM substrate FaGLaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070922(CHEMBL3409525)
Affinity DataKi:  12nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50474089(CHEMBL43228)
Affinity DataKi:  16.6nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50474119(CHEMBL40208)
Affinity DataKi:  18.6nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50396788(CHEMBL2172738)
Affinity DataKi:  19nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50474137(CHEMBL41500)
Affinity DataKi:  19.1nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50396788(CHEMBL2172738)
Affinity DataKi:  19.1nMAssay Description:Binding affinity to Bacillus thermoproteolyticus thermolysin by UV-VIS spectrophotometric analysis in presence of 2-furanacryloyl-Gly-Leu-NH2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070917(CHEMBL3409528)
Affinity DataKi:  24nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070931(CHEMBL3409516)
Affinity DataKi:  26nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50251742((S)-2-{(R)-2-[Hydroxy-((2R,3R,4R,5R,6S)-3,4,5-trih...)
Affinity DataKd:  28nMAssay Description:Binding affinity against ThermolysinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50251742((S)-2-{(R)-2-[Hydroxy-((2R,3R,4R,5R,6S)-3,4,5-trih...)
Affinity DataKi:  28nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50474108(CHEMBL41289)
Affinity DataKi:  28.2nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070938(CHEMBL3409509)
Affinity DataKi:  29nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50442257(CHEMBL2028192)
Affinity DataKi:  30nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin using FA-Fly-Leu-NH2 as substrate at pH 7.5 after 15 mins by Henderson plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070923(CHEMBL3409524)
Affinity DataKi:  31nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50442257(CHEMBL2028192)
Affinity DataKi:  32nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50442257(CHEMBL2028192)
Affinity DataKd:  32nMAssay Description:Binding affinity to Bacillus thermoproteolyticus thermolysin at pH 7.5 after 15 mins by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50251742((S)-2-{(R)-2-[Hydroxy-((2R,3R,4R,5R,6S)-3,4,5-trih...)
Affinity DataIC50: 33nMAssay Description:Inhibitory activity against thermolysin with 0.5 uM [Leu5]-enkephalin (NEN)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50422014(CHEMBL319299)
Affinity DataKi:  33.9nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070933(CHEMBL3409514)
Affinity DataKi:  37nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070920(CHEMBL3409526)
Affinity DataKi:  40nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50121453(Sodium; (S)-2-[(S)-2-({dihydroxy-[(3-phenyl-propio...)
Affinity DataKi:  41nMAssay Description:Competitive inhibition of thermolysin evaluated using the substrate FAGLA (Sigma); Competitive binding observedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50121454((S)-2-[(Aminomethyl-diphenyl-silanyl)-methyl]-4-me...)
Affinity DataKi:  41nMAssay Description:Competitive inhibition of thermolysin evaluated using the substrate FAGLA (Sigma); Competitive binding observedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070930(CHEMBL3409517)
Affinity DataKi:  43nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50474144(CHEMBL287732)
Affinity DataKi:  44.7nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50006117(CHEMBL43735 | (CLT) 2-{1-[1-Carboxy-2-(1H-indol-3-...)
Affinity DataKi:  50nMAssay Description:Inhibitory constant against thermolysin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50422014(CHEMBL319299)
Affinity DataKi:  50nMAssay Description:Tested for binding affinity against ThermolysinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50474113(CHEMBL289703)
Affinity DataKi:  52.5nMAssay Description:pKi value expresses binding affinity against thermolysin pKi = -logKi (where Ki is in mol/L)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Harvard University

Curated by ChEMBL
LigandPNGBDBM50070918(CHEMBL3559407)
Affinity DataKi:  54nMAssay Description:Inhibition of Bacillus thermoproteolyticus TLN using 2-furanacryloyl-Gly-Leu-NH2 substrate by biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
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