Compile Data Set for Download or QSAR
Report error Found 18 Enz. Inhib. hit(s) with Target = 'Telomerase protein component 1'
TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279800(US10035814, Compound 142693 | PMPG free acid, R fo...)
Affinity DataEC50:  1.17E+4nMAssay Description:Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279808(US10035814, Compound 142942 | bis-PMPG spermine)
Affinity DataEC50:  1.84E+3nMAssay Description:Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279807(US10035814, Compound 142962 | PMPG-C10 amidate)
Affinity DataEC50:  1.44E+3nMAssay Description:Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279806(US10035814, Compound 142812 | PMPG spermidine, R f...)
Affinity DataEC50:  5.00E+3nMAssay Description:Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279805(US10035814, Compound 142873 | PMIBeG spermidine)
Affinity DataEC50:  6.70E+3nMAssay Description:Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279804(US10035814, Compound 142820 | PMPeG, prodrug)
Affinity DataEC50:  1.09E+4nMAssay Description:Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279803(US10035814, Compound 142811 | PMIBeG free acid)
Affinity DataEC50:  2.60E+3nMAssay Description:Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279802(US10035814, Compound 142694 | 6-thio-G- phosphonat...)
Affinity DataEC50:  7.54E+3nMAssay Description:Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279801(US10035814, Compound 142715 | PMPG prodrug, R form)
Affinity DataEC50:  2.15E+3nMAssay Description:Telomerase inhibition is observed in cells following the addition of the prodrugs (R)-PMPG-diisopropyloxy ester or (S)-PMPG-diisopropyloxy ester. HT3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279791(US10035814, Compound 142692 | PMPG free acid, R fo...)
Affinity DataEC50:  850nMpH: 8.5Assay Description:(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279799(US10035814, Compound 142879 | PMP(2)G)
Affinity DataEC50:  3.10E+3nMpH: 8.5Assay Description:(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279798(US10035814, Compound 142846 | PMIBaG (mix R,S))
Affinity DataEC50:  4.40E+3nMpH: 8.5Assay Description:(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279797(US10035814, Compound 142810 | PMIBeG, free acid)
Affinity DataEC50:  1.40E+3nMpH: 8.5Assay Description:(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279796(US10035814, Compound 142856 | FPMPG)
Affinity DataEC50:  7.50E+3nMpH: 8.5Assay Description:(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279795(US10035814, Compound 142915 | PM(2)BG)
Affinity DataEC50: >6.00E+4nMpH: 8.5Assay Description:(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
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TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279794(US10035814, Compound 142916 | PM(3)BG)
Affinity DataEC50:  1.00E+4nMpH: 8.5Assay Description:(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279793(US10035814, Compound 142848 | PMPG(lin))
Affinity DataEC50:  1.50E+3nMpH: 8.5Assay Description:(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent

TargetTelomerase protein component 1(Human)
Geron

US Patent
LigandPNGBDBM279792(US10035814, Compound 142761 | 6-thio-G- phosphonat...)
Affinity DataEC50:  1.35E+4nMpH: 8.5Assay Description:(((Guanine-9-yl) propan-2-oxy) methyl) phosphonic acid diphosphate (PMPGpp) acts as a chain terminator and competes with dGTP.Purified human telomera...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2018
Entry Details
Go to US Patent