Compile Data Set for Download or QSAR
Report error Found 1006 Enz. Inhib. hit(s) with Target = 'Squalene synthase'
TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  2.93E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652792(CHEMBL3752910)
Affinity DataKd:  3.81E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029174([3-(3-Allyl-biphenyl-4-yloxy)-propyl]-isopropyl-am...)
Affinity DataIC50: 0.00400nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038093((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.0400nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038102((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.0400nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029177(Propionic acid 3-allyl-4-(3-isopropylamino-propoxy...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038087((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.0600nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038138((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.0700nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038092((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.0900nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038089((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.120nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038120((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.130nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038123((6R,7R)-4,7-Dihydroxy-1-(5-methyl-6-phenyl-hexyl)-...)
Affinity DataIC50: 0.140nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038122((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.160nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038121((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.170nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038151((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.190nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038091((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.190nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029166(Acetaldehyde O-[3-allyl-4-(3-isopropylamino-propox...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038090((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.200nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038125((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.200nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50292336(desacetoxy-zaragozic acid | CHEMBL507677)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article

TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50292415(Zaragozic Acid B | CHEMBL504845)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of rat liver squalene synthase by liqiud scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038119((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.210nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038096((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.230nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038103((6R,7R)-6-((E)-(4S,6S)-4,6-Dimethyl-oct-2-enoyloxy...)
Affinity DataIC50: 0.240nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50038096((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.240nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038114((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.260nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038135((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.280nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50038102((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.280nMAssay Description:compound required to inhibit 50% activity of yeast squalene synthase enzyme (YESS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038096((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.290nMAssay Description:In vitro inhibitory activity against rat squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50038089((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.300nMAssay Description:compound required to inhibit 50% activity of yeast squalene synthase enzyme (YESS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50292333(zaragozic acid C | CHEMBL505374)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article

TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50442114(CHEMBL2441090)
Affinity DataIC50: 0.360nMAssay Description:Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038127((6R,7R)-1-(4-Acetoxy-5-methyl-6-phenyl-hexyl)-4,7-...)
Affinity DataIC50: 0.370nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038128((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.380nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50292333(zaragozic acid C | CHEMBL505374)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of rat liver squalene synthase by liqiud scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038104((6R,7R)-6-((E)-(4S,6S)-4,6-Dimethyl-oct-2-enoyloxy...)
Affinity DataIC50: 0.420nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50338903(Ethyl 1-{4-[{4-chloro-2-[(2-fluorophenyl)(hydroxy)...)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50051873((1S,3S,4S,5R,6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rat liver squalene synthase by liqiud scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388376(CHEMBL2057637)
Affinity DataIC50: 0.510nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038101((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.520nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50285068((S)-2-{[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50: 0.520nMAssay Description:Inhibitory activity against squalene synthase (SQS) obtained from HepG2 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50285068((S)-2-{[(1S,2S)-3-(3,4-Dichloro-phenyl)-2-(2-fluor...)
Affinity DataIC50: 0.520nMAssay Description:Inhibitory activity against HepG2 Squalene Synthase (SQS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388375(CHEMBL2057636)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029159([3-(2-Allyl-4-butoxy-phenoxy)-propyl]-isopropyl-am...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50029171(N-[3-Benzyl-4-(3-isopropylamino-propoxy)-phenyl]-p...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of rat microsomal squalene synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50643835(CHEMBL5583916)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSqualene synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50038093((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.640nMAssay Description:compound required to inhibit 50% activity of yeast squalene synthase enzyme (YESS)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50038088((6R,7R)-1-((4S,5R)-4-Acetoxy-5-methyl-3-methylene-...)
Affinity DataIC50: 0.660nMAssay Description:Tested for inhibition against squalene synthase enzyme in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388378(CHEMBL2057639)
Affinity DataIC50: 0.680nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSqualene synthase(Rat)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50388348(CHEMBL2057952)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of squalene synthase in rat hepatic cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
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