Compile Data Set for Download or QSAR
Report error Found 58 Enz. Inhib. hit(s) with Target = 'Sphingolipid delta(4)-desaturase DES1'
LigandPNGBDBM523252(US11135207, Example 32 | (1r,4r)-4-(4- chloropheny...)
Affinity DataIC50: 1nMAssay Description:Inhibition of DES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523251(US11135207, Example 31 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 1nMAssay Description:Inhibition of DES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523252(US11135207, Example 32 | (1r,4r)-4-(4- chloropheny...)
Affinity DataIC50: 1nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523251(US11135207, Example 31 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 1nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523268(US11135207, Example 53 | N-(5-hydroxypyridin-2-yl)...)
Affinity DataIC50: 2nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523246(US11135207, Example 24 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 3nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523270(US11135207, Example 57 | 2-[1-(5-chloropyridin-2-y...)
Affinity DataIC50: 3.90nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523243(US11135207, Example 20 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 4nMAssay Description:Inhibition of DES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523254(US11135207, Example 35 | 4-(tert-butyl)- N-(5-hydr...)
Affinity DataIC50: 4nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523243(US11135207, Example 20 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 4nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523266(US11135207, Example 51 | 2-[1-(4-chlorophenyl)pipe...)
Affinity DataIC50: 5nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523249(US11135207, Example 28 | (1r,4r)-N-(5- hydroxy- py...)
Affinity DataIC50: 5nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523245(US11135207, Example 23 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 5nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM50407243(CHEMBL5275998)
Affinity DataIC50: 6nMAssay Description:Inhibition of rat liver microsome DES1 using N-octanoylsphinganine as substrate incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523250(US11135207, Example 29 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 6nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523236(US11135207, Example 9 | N-(5-hydroxy- pyridin-2-yl...)
Affinity DataIC50: 10nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523269(US11135207, Example 54 | 1-(4-fluorophenyl)-N-(5-h...)
Affinity DataIC50: 11nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523264(US11135207, Example 49 | 2-[1-(4-fluorophenyl) pip...)
Affinity DataIC50: 13nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523244(US11135207, Example 22 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 14nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523248(US11135207, Example 27 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 16nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523256(US11135207, Example 38 | 2'-chloro-N- (5-hydroxy- ...)
Affinity DataIC50: 19nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523255(US11135207, Example 37 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 21nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523257(US11135207, Example 40 | (1r,4r)-N-(5- hydroxypyri...)
Affinity DataIC50: 21nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent

LigandPNGBDBM523261(US11135207, Example 45 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 23nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523262(US11135207, Example 47 | N-(5-hydroxypyridin-2-yl)...)
Affinity DataIC50: 50nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523232(US11135207, Example 5 | N-(4-hydroxy- phcnyl)-[1,1...)
Affinity DataIC50: 50nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM50407243(CHEMBL5275998)
Affinity DataIC50: 52nMAssay Description:Inhibition of DES1 in human HGC-27 cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523235(US11135207, Example 8 | N-(5-hydroxy- pyridin-2-yl...)
Affinity DataIC50: 60nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523260(US11135207, Example 44 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 63nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523267(US11135207, Example 52 | 2-[4-(4-chlorophenyl)pipe...)
Affinity DataIC50: 66nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523258(US11135207, Example 41 | (1s,4s)-N-(5- hydroxypyri...)
Affinity DataIC50: 88nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523241(US11135207, Example 15 | N-(4-hydroxy- phenyl)-4- ...)
Affinity DataIC50: 90nMAssay Description:Inhibition of DES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523241(US11135207, Example 15 | N-(4-hydroxy- phenyl)-4- ...)
Affinity DataIC50: 90nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM50092055(CHEMBL7301 | N-(4-hydroxyphenyl)-retinamide | 4-hy...)
Affinity DataIC50: 100nMAssay Description:Inhibition of DES1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523253(US11135207, Example 34 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 130nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523259(US11135207, Example 42 | 4-ethyl-N-(5- hydroxy- py...)
Affinity DataIC50: 130nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523265(US11135207, Example 50 | 2-[4-(4-fluorophenyl)pipe...)
Affinity DataIC50: 140nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM50407244(CHEMBL5268107)
Affinity DataIC50: 155nMAssay Description:Inhibition of DES1 in human HGC-27 cell lysatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523234(US11135207, Example 7 | N-(5-hydroxy- pyridin-2-yl...)
Affinity DataIC50: 180nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523237(US11135207, Example 10 | (trans)-N-(5- hydroxy- py...)
Affinity DataIC50: 230nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523247(US11135207, Example 26 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 240nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523263(US11135207, Example 48 | 1-(4-fluorophenyl)-N-(5-h...)
Affinity DataIC50: 250nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM50429763(N-(4-Hydroxyphenyl)Cinnamamide | CHEMBL229844 | US...)
Affinity DataIC50: 440nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523233(US11135207, Example 6 | (trans)-N-(4- hydroxypheny...)
Affinity DataIC50: 590nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523229(US11135207, Example 2 | N-(4-hydroxy- phenyl)-2- n...)
Affinity DataIC50: 840nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM50407241(CHEMBL5290345)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of rat liver microsome DES1 incubated for 20 min in presence of NADH by liquid scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM50092055(CHEMBL7301 | N-(4-hydroxyphenyl)-retinamide | 4-hy...)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of rat liver microsome DES1 incubated for 20 min in presence of NADH by liquid scintillation counter methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
LigandPNGBDBM523230(US11135207, Example 3 | (E)-N-(4- hydroxy- phenyl)...)
Affinity DataIC50: 4.46E+3nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM523242(US11135207, Example 18 | N-(5-hydroxy- pyridin-2-y...)
Affinity DataIC50: 4.50E+3nMAssay Description:Jurkat clone E6-1 cells were grown and then seeded at 106 cells/mL in a 96-well plate (400 μL in each well. The cells were administered 100 _...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
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LigandPNGBDBM50407242(CHEMBL5277675)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of rat liver microsome DES1 incubated for 1 hr fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
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