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Report error Found 18 Enz. Inhib. hit(s) with Target = 'Spermidine synthase'
TargetSpermidine synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  211nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSpermidine synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50369035(CHEMBL608868)
Affinity DataIC50: 3nMAssay Description:Inhibition of prokaryotic Escherichia coli Putrescine aminopropyltransferase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSpermidine synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50369035(CHEMBL608868)
Affinity DataIC50: 14nMAssay Description:Inhibition of Putrescine aminopropyl transferase (PAPT) in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSpermidine synthase(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095449(2-[1-(2-Amino-ethyl)-6-(3-amino-propylamino)-hexyl...)
Affinity DataIC50: 50nMAssay Description:Inhibition of Spermidine aminopropyltransferase (SAPT) in rat liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSpermidine synthase(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095450(2-[6-Amino-1-(2-amino-ethyl)-hexylsulfanylmethyl]-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Putrescine aminopropyl transferase (PAPT) in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSpermidine synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50095450(2-[6-Amino-1-(2-amino-ethyl)-hexylsulfanylmethyl]-...)
Affinity DataIC50: 250nMAssay Description:Inhibition of prokaryotic Escherichia coli Putrescine aminopropyltransferase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSpermidine synthase(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095450(2-[6-Amino-1-(2-amino-ethyl)-hexylsulfanylmethyl]-...)
Affinity DataIC50: 400nMAssay Description:Inhibitory activity against spermidine synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetSpermidine synthase(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50369035(CHEMBL608868)
Affinity DataIC50: 750nMAssay Description:Inhibition of Spermidine aminopropyltransferase (SAPT) in rat liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSpermidine synthase(malaria parasite P. falciparum)
Inovacia

Curated by ChEMBL
LigandPNGBDBM50261173(cis-4-methylcyclohexanamine | 4-methylcyclohexylam...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Plasmodium falciparum spermidine synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSpermidine synthase(Pig)
National Institute of Advanced Industrial Science and Technology (Aist)

Curated by ChEMBL
LigandPNGBDBM50152094(CHEMBL3780789)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of porcine spermidine synthase assessed as production of labeled 5'-methylthioadenosine using putrescine as substrate by enzymatic assay i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetSpermidine synthase(Human)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50365463(CHEMBL1232461)
Affinity DataIC50: 3.90E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSpermidine synthase(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095449(2-[1-(2-Amino-ethyl)-6-(3-amino-propylamino)-hexyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Putrescine aminopropyltransferase (PAPT) in rat liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSpermidine synthase(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50404650(CHEMBL557606)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory activity against spermidine synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetSpermidine synthase(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50404650(CHEMBL557606)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibitory activity against spermine synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetSpermidine synthase(malaria parasite P. falciparum)
Inovacia

Curated by ChEMBL
LigandPNGBDBM22111((2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfa...)
Affinity DataIC50: 1.59E+5nMAssay Description:Inhibition of Plasmodium falciparum spermidine synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSpermidine synthase(Pig)
National Institute of Advanced Industrial Science and Technology (Aist)

Curated by ChEMBL
LigandPNGBDBM50151659(CHEMBL3775244)
Affinity DataIC50: 1.90E+5nMAssay Description:Inhibition of yeast ESA1 using N-terminal histone H3 substrate by radiometric filter binding based virtual screen in presence of [3H]acetyl-CoAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetSpermidine synthase(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095450(2-[6-Amino-1-(2-amino-ethyl)-hexylsulfanylmethyl]-...)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Spermidine aminopropyltransferase (SAPT) in rat liver.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/29/2012
Entry Details Article
PubMed
TargetSpermidine synthase(Rat)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50404649(CHEMBL178068)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibitory activity against spermidine synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed