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Report error Found 30 Enz. Inhib. hit(s) with Target = 'Solute carrier family 5 member 4'
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342885((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)
Affinity DataIC50: 0.877nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342887((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-methoxybenzyl)ph...)
Affinity DataIC50: 0.882nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342889((1S,2S,3S,4R,5S)-1-(Hydroxymethyl)-5-[3-(4-methoxy...)
Affinity DataIC50: 1.07nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342888((1S,2S,3S,4R,5S)-5-[3-(4-Ethoxybenzyl)-4-methylphe...)
Affinity DataIC50: 1.11nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20880(CHEMBL429910 | C-aryl glucoside, 6 | BMS-512148 | ...)
Affinity DataIC50: 1.35nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20878((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50313368((6S,7R,8R,9S)-6-(3-(4-methoxybenzyl)-4-methylpheny...)
Affinity DataIC50: 6.98nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351435(CHEMBL1819489)
Affinity DataIC50: 11nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM20875(CHEMBL245067 | JMC511145 Compound 1 | 1-(2,4-dihyd...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351439(CHEMBL1819492)
Affinity DataIC50: 19nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351432(CHEMBL1819486)
Affinity DataIC50: 28nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351436(CHEMBL1819490)
Affinity DataIC50: 29nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351437(CHEMBL1819491)
Affinity DataIC50: 42nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342886((1S,2S,3S,4S,5S)-5-[4-Chloro-3-(4-methoxybenzyl)-p...)
Affinity DataIC50: 43.1nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351431(CHEMBL1819485)
Affinity DataIC50: 59nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345019((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(4-(pent-2...)
Affinity DataIC50: 59.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345022((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(15-oxa-tricycl...)
Affinity DataIC50: 81.9nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345020((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(15-oxa-tricycl...)
Affinity DataIC50: 89.6nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50342884((1S,2S,3S,4S,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)-ph...)
Affinity DataIC50: 89.9nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345023((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(16-oxa-tricycl...)
Affinity DataIC50: 99.7nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50345021((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(16-oxa-tricycl...)
Affinity DataIC50: 103nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351438(CHEMBL1817688)
Affinity DataIC50: 110nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351433(CHEMBL1819487)
Affinity DataIC50: 120nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351443(CHEMBL1819496)
Affinity DataIC50: 120nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351434(CHEMBL1819488)
Affinity DataIC50: 150nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351442(CHEMBL1819495)
Affinity DataIC50: 150nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351429(CHEMBL450044)
Affinity DataIC50: 260nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351440(CHEMBL1819493)
Affinity DataIC50: 290nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351441(CHEMBL1819494)
Affinity DataIC50: 630nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSolute carrier family 5 member 4(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50351430(CHEMBL1819484)
Affinity DataIC50: 690nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed