Compile Data Set for Download or QSAR
Report error Found 176 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 3 subunit alpha'
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50242400(CCNCSSKWCRDHSRCC | CHEMBL525818)
Affinity DataKd:  4.60E+3nMAssay Description:Inhibition of rat Nav1.3 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  2.20E+3nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataKd:  110nMAssay Description:Binding affinity to human recombinant Nav1.3 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataKd:  180nMAssay Description:Binding affinity to human recombinant Nav1.3 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of full length human Nav1.3 expressed in HEK293 cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50582054(CHEMBL5091679)
Affinity DataEC50:  135nMAssay Description:Modulator activity at rat Nav1.3 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50582055(CHEMBL5083412)
Affinity DataEC50:  128nMAssay Description:Modulator activity at rat Nav1.3 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50582056(CHEMBL5091623)
Affinity DataEC50:  139nMAssay Description:Modulator activity at rat Nav1.3 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50582057(CHEMBL5077579)
Affinity DataEC50:  13nMAssay Description:Modulator activity at rat Nav1.3 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50582058(CHEMBL5093878)
Affinity DataEC50:  9.40nMAssay Description:Modulator activity at rat Nav1.3 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50582059(CHEMBL5082582)
Affinity DataEC50:  106nMAssay Description:Modulator activity at rat Nav1.3 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50582060(CHEMBL5084333)
Affinity DataEC50:  170nMAssay Description:Modulator activity at rat Nav1.3 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50: 13nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50077471(CHEMBL3416886)
Affinity DataIC50: 20nMAssay Description:Inhibition of human NaV1.3 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2016
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50118516(CHEMBL3617053)
Affinity DataIC50: 20nMAssay Description:Inhibition of human TTX-sensitive NaV1.3 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50: 25nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: 30nMAssay Description:Inhibition of voltage-gated Na channel 1.3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50426577(CHEMBL2324354)
Affinity DataIC50: 30nMAssay Description:Inhibition of human voltage-gated Na channel 1.3More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50520478(CHEMBL4436427)
Affinity DataIC50: 110nMAssay Description:Inhibition of Nav1.3 (unknown origin) expressed in Xenopus laevis oocytes at -80 mV holding potential by two electrode voltage-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50520499(CHEMBL4517378)
Affinity DataIC50: 200nMAssay Description:Inhibition of Nav1.3 (unknown origin) expressed in Xenopus laevis oocytes at -80 mV holding potential by two electrode voltage-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50: 210nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50520496(CHEMBL4469517)
Affinity DataIC50: 260nMAssay Description:Inhibition of Nav1.3 (unknown origin) expressed in Xenopus laevis oocytes at -80 mV holding potential by two electrode voltage-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50257215(CHEMBL2324411)
Affinity DataIC50: 292nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2019
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50349984(CHEMBL1813048)
Affinity DataIC50: 300nMAssay Description:Inhibition of 20% inactivated TTX-resistant human sodium channel Nav1.3 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50118517(CHEMBL3617067)
Affinity DataIC50: 375nMAssay Description:Inhibition of rat NaV1.3 channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50300204((R)-N-benzyl 2-acetamido-3-methoxypropionamide, | ...)
Affinity DataIC50: 415nMAssay Description:Binding affinity to rat inactivated voltage-gated Na channel 1.3 expressed in human HEK293 cells by patch-clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50017659(Diaethylaminoaethanol ester der p-butylaminobenzoe...)
Affinity DataIC50: 740nMAssay Description:Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50371391(SENICAPOC)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of voltage-gated Na channel 1.3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50004782(CHEMBL2324353)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of rat voltage-gated Na channel 1.3 in dorsal root ganglion neurons by patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of inactivated human Nav1.3 sodium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of human Nav1.3 channel expressed in HEK293 cells at -60 mV by patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50257182(CHEMBL2324753)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2019
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50500961(CHEMBL3798363)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50095314(CHEMBL3589893)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50563816(Eleclazine | GS-6615)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of NaV1.3 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50008745(CHEMBL3236329)
Affinity DataIC50: 4.76E+3nMAssay Description:Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50: 6.44E+3nMAssay Description:Inhibition of human Nav1.3 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50095313(CHEMBL3589892)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human Nav1.3 expressed in CHO cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2019
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM344708(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50242400(CCNCSSKWCRDHSRCC | CHEMBL525818)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of rat Nav1.3 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50495865(CHEMBL3113259)
Affinity DataIC50: 8.00E+3nMAssay Description:Modulation of human Nav1.3 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50118514(US9481677, 38 | CHEMBL3617063)
Affinity DataIC50: 9.33E+3nMAssay Description:Inhibition of full length human Nav1.3 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -50 mV by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2017
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50095312(CHEMBL2324355)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.3 expressed in SHSY5Y cells by IonWorks Quattro selectivity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2016
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50349984(CHEMBL1813048)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of fully inactivated TTX-resistant human sodium channel Nav1.3 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50257175(CHEMBL2324776)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2019
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50240267(CHEMBL2325014)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2019
Entry Details Article
PubMed
TargetSodium channel protein type 3 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50257177(CHEMBL2324748)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2019
Entry Details Article
PubMed
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