Compile Data Set for Download or QSAR
Report error Found 1721 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 1 subunit alpha'
TargetSodium channel protein type 1 subunit alpha(Rat)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50242400(CCNCSSKWCRDHSRCC | CHEMBL525818)
Affinity DataKd:  290nMAssay Description:Inhibition of rat Nav1.1 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha [1489-1708](Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118518(CHEMBL3617066)
Affinity DataKd:  290nMAssay Description:Inhibition of mouse NaV1.1 channel by two-electrode voltage-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM168436(US9675591, SKA-19)
Affinity DataEC50:  6.90E+3nMpH: 7.35 T: 2°CAssay Description:All experiments were conducted at room temperature (22-24° C.) with an EPC-10 amplifier and Pulse software (HEKA, Lambrecht/Pfalz, Germany) in the wh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2018
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataKd:  140nMAssay Description:Binding affinity to human recombinant Nav1.1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataKd:  140nMAssay Description:Binding affinity to human recombinant Nav1.1 by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50521571(CHEMBL4464990)
Affinity DataKd: >1.00E+3nMAssay Description:Inhibition of full length human Nav1.1 expressed in CHO cells at -60 mV holding potential by manual patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50582054(CHEMBL5091679)
Affinity DataEC50:  124nMAssay Description:Modulator activity at human Nav1.1 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50582055(CHEMBL5083412)
Affinity DataEC50:  126nMAssay Description:Modulator activity at human Nav1.1 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50582056(CHEMBL5091623)
Affinity DataEC50:  126nMAssay Description:Modulator activity at human Nav1.1 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50582057(CHEMBL5077579)
Affinity DataEC50:  92nMAssay Description:Modulator activity at human Nav1.1 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50582058(CHEMBL5093878)
Affinity DataEC50:  102nMAssay Description:Modulator activity at human Nav1.1 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50582059(CHEMBL5082582)
Affinity DataEC50:  7.90nMAssay Description:Modulator activity at human Nav1.1 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50582060(CHEMBL5084333)
Affinity DataEC50:  172nMAssay Description:Modulator activity at human Nav1.1 expressed in Xenopus laevis oocytes assessed as elicitation in sodium current measured after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: 4.10nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50: 6nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM145591(US8952169, 389)
Affinity DataIC50: 6nMAssay Description:Inhibition of human Nav1.1 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -40 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50: 11nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50: 11nMAssay Description:Inhibition of full length human Nav1.1 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50: 16nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50118516(CHEMBL3617053)
Affinity DataIC50: 20nMAssay Description:Inhibition of human NaV1.1 channel by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: 30nMAssay Description:Inhibition of voltage-gated Na channel 1.1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM525934(5-chloro-2-fluoro-N-(thiazol-2-yl)-4-((3,3,3-trifl...)
Affinity DataIC50: 31nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50: 37nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM268418(N-(7-(adamantan-1-ylmethoxy)-6-ethyl-[1,2,4]triazo...)
Affinity DataIC50: 45nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.1 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM145466(US8952169, 245)
Affinity DataIC50: 48nMAssay Description:Inhibition of human Nav1.1 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -40 mV holding potential by PatchXpress automated v...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM526158((S)-5-chloro-2-fluoro-N-(5-fluorothiazol-2-yl)-4-(...)
Affinity DataIC50: 50nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM268423(N-(7-((3r,5r,7r)-adamantan-1-ylmethoxy)-6-cyclopro...)
Affinity DataIC50: 53nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.1 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50568138(CHEMBL4854735)
Affinity DataIC50: 90nMAssay Description:Inhibition of human Nav1.1 by V1/2 protocol based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50505257(CHEMBL4471012)
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.1 at -45 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM268527(US9550775, 106 | N-(6-cyclopropyl-7-((3,5-dichloro...)
Affinity DataIC50: 112nMAssay Description:Inhibition of inactivated state of recombinant human NaV1.1 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM525920((S)-2,6-difluoro-4-((1-(2-fluorophenyl)ethyl)amino...)
Affinity DataIC50: 112nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM525940((S)-5-chloro-2-fluoro-4-((1-(2-fluorophenyl)propyl...)
Affinity DataIC50: 114nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM526159((S)-5-chloro-2-fluoro-4-((1-(2-fluorophenyl)ethyl)...)
Affinity DataIC50: 133nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM525987(5-chloro-2-fluoro-4-((5,6,7,8-tetrahydroisoquinoli...)
Affinity DataIC50: 142nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM526019((S)-2-fluoro-5-methyl-4-((1-phenylpropyl)thio)-N-(...)
Affinity DataIC50: 147nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM526036(5-chloro-2-fluoro-4-(3-methyl-1-phenylbutylamino)-...)
Affinity DataIC50: 159nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM525933((S)-5-chloro-2-fluoro-4-((1-phenylpropyl)amino)-N-...)
Affinity DataIC50: 182nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM76858(US9694002, 580 | US9546164, 580)
Affinity DataIC50: 192nMAssay Description:Inhibition of human Nav1.1 at -45 mV holding potential by manual patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM70937(US9694002, 100 | US9546164, 100)
Affinity DataIC50: 202nMAssay Description:Inhibition of full length human Nav1.1 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2023
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50257215(CHEMBL2324411)
Affinity DataIC50: 216nMAssay Description:Inhibition of human NaV1.1 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2019
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM492965(US10981905, Example 36 | 5-((2-bromo-3,6-difluorob...)
Affinity DataIC50: 245nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM492965(US10981905, Example 36 | 5-((2-bromo-3,6-difluorob...)
Affinity DataIC50: 245nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM525942((S)-5-chloro-2-fluoro-4-((1-(3-fluorophenyl)ethyl)...)
Affinity DataIC50: 260nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM526034(5-chloro-2-fluoro-4-(1-phenylpropylamino)-N-(thiaz...)
Affinity DataIC50: 277nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM525954(5-chloro-2-fluoro-4-((isoquinolin-8-ylmethyl)amino...)
Affinity DataIC50: 283nMAssay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM525928((R)-3-chloro-4-((2,3-dihydro-1H-inden-1-yl)amino)-...)
Affinity DataIC50: 301nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM525991(5-chloro-2-fluoro-4-((5,6,7,8-tetrahydroquinolin-5...)
Affinity DataIC50: 303nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2022
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50: 309nMAssay Description:Inhibition of human Nav1.1 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSodium channel protein type 1 subunit alpha(Human)
University of California

US Patent
LigandPNGBDBM50451447(CHEMBL4217988)
Affinity DataIC50: 310nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
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