Compile Data Set for Download or QSAR
Report error Found 229 Enz. Inhib. hit(s) with Target = 'Serine protease hepsin'
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580332(CHEMBL5081575)
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639175(CHEMBL5558547)
Affinity DataIC50: 0.170nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639183(CHEMBL5568169)
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639177(CHEMBL5564865)
Affinity DataIC50: 0.330nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580346(CHEMBL5074750)
Affinity DataIC50: 0.380nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639180(CHEMBL5559738)
Affinity DataIC50: 0.540nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639179(CHEMBL5560415)
Affinity DataIC50: 0.690nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639176(CHEMBL5560759)
Affinity DataIC50: 0.910nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639172(CHEMBL5561725)
Affinity DataIC50: 0.990nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580331(CHEMBL5083517)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639178(CHEMBL5557087)
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50063698(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580335(CHEMBL5092327)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580342(CHEMBL5088958)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580337(CHEMBL5081090)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580343(CHEMBL5086585)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639173(CHEMBL5555448)
Affinity DataIC50: 6.30nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639184(CHEMBL5557551)
Affinity DataIC50: 7.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580339(CHEMBL5084226)
Affinity DataIC50: 7.80nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580334(CHEMBL5081335)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580338(CHEMBL5077855)
Affinity DataIC50: 8.80nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580340(CHEMBL5078472)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580333(CHEMBL5081508)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639182(CHEMBL5559988)
Affinity DataIC50: 14nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580347(CHEMBL5091091)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580344(CHEMBL5075134)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639174(CHEMBL5562350)
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272185(CHEMBL4129836)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580341(CHEMBL5091578)
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580330(CHEMBL5075263)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50424712(Camostat Mesilate | Foipan | CAMOSTAT)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272310(CHEMBL4130135)
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639185(CHEMBL5558228)
Affinity DataIC50: 37nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272310(CHEMBL4130135)
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580345(CHEMBL5081851)
Affinity DataIC50: 44nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272187(CHEMBL4128554)
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50518596(CHEMBL4463174)
Affinity DataIC50: 92nMAssay Description:Inhibition of hepsin (unknown origin) expressed in MCF10A cells preincubated for 30 mins followed by Boc-QAR-AMC substrate addition and measured for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272185(CHEMBL4129836)
Affinity DataIC50: 100nMAssay Description:Inhibition of doxycycline induced Hepsin in human MCF10A cells using Boc-QRR-AMC as substrate preincubated for 24 hrs followed by doxycycline inducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272184(CHEMBL4126579)
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50580336(CHEMBL5091873)
Affinity DataIC50: 136nMAssay Description:Inhibition of recombinant human C-terminal 10-His tagged hepsin (Arg45 to Leu417) expressed in mouse myeloma cells using Boc-QAR-AMC as substrate pre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50639181(CHEMBL5556134)
Affinity DataIC50: 137nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272187(CHEMBL4128554)
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272280(CHEMBL4127165)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50041802(CHEMBL46469 | 1,8-dihydroxyanthrone | 1,8-dihydrox...)
Affinity DataIC50: 230nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272180(CHEMBL4128355)
Affinity DataIC50: 250nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50066614(2,7-di[1-[4-amino(imino)methylphenyl]-(E)-methylid...)
Affinity DataIC50: 272nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM123129(CID236790 | 1-(3-nitro-phenyl)-pyrrole-2,5-dione (...)
Affinity DataIC50: 280nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272349(CHEMBL4125890)
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM191639(US9182402, 12)
Affinity DataIC50: 330nMAssay Description:To identify novel inhibitors of hepsin, the Chembridge DIVERSet 10,000 compound high-diversity library was screened using an assay based on the cleav...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2016
Entry Details
Go to US Patent

TargetSerine protease hepsin(Human)
Washington University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50272222(CHEMBL4128356)
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant C-terminal His10-tagged human Hepsin (R45 to L17 residues) D161E/ R162K double mutant expressed in mouse NS0 cells using Bo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/1/2020
Entry Details Article
PubMed
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