Compile Data Set for Download or QSAR
Report error Found 497 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein phosphatase'
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in E275RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild typeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D220VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110686(14-Ethylidene-2-isopropyl-5-(6-methoxy-3,5-dimethy...)
Affinity DataIC50: 0.0300nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 0.0650nMAssay Description:Observed inhibition activity of the compounds against protein phosphatases 2A (PP2A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50110676(okadaic acid | CHEMBL280487)
Affinity DataIC50: 0.0700nMAssay Description:Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 0.100nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 0.100nMAssay Description:Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 0.130nMAssay Description:Tested for inhibition of purified catalytic subunit of protein phosphatase-2A from human erythrocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2012
Entry Details Article

TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D220VMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 0.200nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061066((5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guan...)
Affinity DataIC50: 0.200nMAssay Description:Observed inhibition activity against protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform(Bovine)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human PP2AC using [3H]-phosphohistone as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110685(25-Isobutyl-15-(6-methoxy-3,5-dimethyl-7-phenyl-he...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of microcystin analogues to catalytic subunits of Serine/threonine protein phosphatase 2A (PP2Ac)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform(Bovine)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50135699((5R,8S,11R,12S,15S,18S,19S,22R)-8-Isobutyl-18-((1E...)
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against protein phosphatase 2A (PP2A) using phosphorylase-a assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in E275RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110676(okadaic acid | CHEMBL280487)
Affinity DataIC50: 0.450nMAssay Description:Observed inhibition activity against protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 0.450nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in wild typeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50646842(CHEMBL5593159)
Affinity DataKd:  0.540nMAssay Description:Binding affinity to human PP5 extracted from Escherichia coli BL21 using immobilized CDC37 as substrate assessed as increase in PP5 binding to substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in C127SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50366883(TAUTOMYCIN)
Affinity DataIC50: 0.700nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in Y272FMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061066((5R,6S,9S,12S,13S,16R)-2-Eth-(Z)-ylidene-9-(3-guan...)
Affinity DataIC50: 1nMAssay Description:Inhibition activity against protein phosphatase 2A (PP2A), activity taken from literatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110676(okadaic acid | CHEMBL280487)
Affinity DataIC50: 1nMAssay Description:Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110676(okadaic acid | CHEMBL280487)
Affinity DataIC50: 1nMAssay Description:Inhibition activity against protein phosphatase 2A (PP2A), activity taken from literatureMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PP5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110676(okadaic acid | CHEMBL280487)
Affinity DataIC50: 1nMAssay Description:Concentration required to inhibit the action of protein phosphatase 2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PPP5C (unknown origin) phosphatase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase 2A activator(Human)
The University of Tokyo

LigandPNGBDBM40776(Calyculin F (23) | Calyculin E (22) | Calyculin B ...)
Affinity DataIC50: 1nMAssay Description:Protein phosphatase inhibitory activity of calyculin derivatives.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50110690(CHEMBL17377 | Phosphoric acid mono-{3,10-dihydroxy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PPP5C (unknown origin) phosphatase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase 2A activator(Human)
The University of Tokyo

LigandPNGBDBM40777(Hemicalyculin A (5))
Affinity DataIC50: 1nMAssay Description:Protein phosphatase inhibitory activity of calyculin derivatives.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50110690(CHEMBL17377 | Phosphoric acid mono-{3,10-dihydroxy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PP5 (unknown origin) using [3H]-phosphohistone as substrate by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase with EF-hands 1(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50110690(CHEMBL17377 | Phosphoric acid mono-{3,10-dihydroxy...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PP7 (unknown origin) phosphatase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase 6 catalytic subunit(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50408820(CHEMBL5268133)
Affinity DataIC50: 1nMAssay Description:Inhibition of PP6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50367033(COENZYME_A)
Affinity DataEC50:  1nMAssay Description:Activation of PPP5C (unknown origin) TPR domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase 2A activator(Human)
The University of Tokyo

LigandPNGBDBM40787(Des-N-methylcalyculin A (20))
Affinity DataIC50: 1nMAssay Description:Protein phosphatase inhibitory activity of calyculin derivatives.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details Article
PubMed
LigandPNGBDBM50004699(CHEMBL96862 | CHEBI:45262 | US11185100, TABLE 9.3)
Affinity DataKd:  1.10nMAssay Description:Binding affinity against Purine Nucleoside PhosphataseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A activator(Human)
The University of Tokyo

LigandPNGBDBM40782(C1/C34-Calyculin A (15))
Affinity DataIC50: 1.10nMAssay Description:Protein phosphatase inhibitory activity of calyculin derivatives.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50408824(CHAULMOOGRIC ACID | CHEBI:61391 | Chaulmoogric Aci...)
Affinity DataEC50:  1.30nMAssay Description:Activation of recombinant human PP5 (16 to 499 residues) Escherichia coli BL21 (DE3) using pNPP incubated for 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase 6 regulatory subunit 1(Homo sapiens)
Johann Wolfgang Goethe University

Curated by ChEMBL
LigandPNGBDBM50652793(CHEMBL5653589)
Affinity DataKd:  1.40nMAssay Description:Binding affinity to human PPP6R1 incubated for 45 mins by Kinobead based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110700(7-Cyclohexyl-25-isobutyl-15-(6-methoxy-3,5-dimethy...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of microcystin analogues to catalytic subunits of Serine/threonine protein phosphatase 2A (PP2Ac)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A activator(Human)
The University of Tokyo

LigandPNGBDBM40785(Calyculinamide A (18))
Affinity DataIC50: 1.5nMAssay Description:Protein phosphatase inhibitory activity of calyculin derivatives.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110682(25-Isobutyl-15-(6-methoxy-3,5-dimethyl-7-phenyl-he...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of microcystin analogues to catalytic subunits of Serine/threonine protein phosphatase 2A (PP2Ac)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50061067(8-[3-amino(imino)methylaminopropyl]-15-isobutyl-5-...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in D208AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B(Chicken)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 2nMAssay Description:Concentration required to inhibit the action of protein phosphatase 2AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A activator(Human)
The University of Tokyo

LigandPNGBDBM40780(Calyculin A 21-acetate (13))
Affinity DataIC50: 2.10nMAssay Description:Protein phosphatase inhibitory activity of calyculin derivatives.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase PP1-gamma catalytic subunit(Human)
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM50110681(Calyculin-A | CHEMBL430266)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutants by natural toxins in C127SMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 2A activator(Human)
The University of Tokyo

LigandPNGBDBM40790(Calyculin C (24))
Affinity DataIC50: 2.60nMAssay Description:Protein phosphatase inhibitory activity of calyculin derivatives.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein phosphatase 4 catalytic subunit(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50110690(CHEMBL17377 | Phosphoric acid mono-{3,10-dihydroxy...)
Affinity DataIC50: 3nMAssay Description:Inhibition of PP4 (unknown origin) phosphatase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSerine/threonine-protein phosphatase 5(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50647778(CHEMBL5597987)
Affinity DataIC50: 3nMAssay Description:Inhibition of human PPP5C (169 to 499 residues) expressed in Escherichia coli using [32P]-phosphohistone as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
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