Compile Data Set for Download or QSAR
Report error Found 271 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase N1'
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM199250(US9221808, 1bo-HCl | US9221808, 1bo-Mes | US922180...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PKN1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652948(CHEMBL3597011)
Affinity DataIC50: 1nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652943(CHEMBL5687042)
Affinity DataIC50: 1nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PKN1 (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  1.30nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataKd:  1.30nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM31096(CHEMBL290084 | Staurosporine | cid_451705 | US2024...)
Affinity DataKd:  1.30nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652945(CHEMBL5687026)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM130909(US8822500, Stauro- sporine | US9920060, Staurospor...)
Affinity DataIC50: 2nMAssay Description:Inhibition of human PKN1 using KKLNRTLSVA as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition and measured after 120 mins by r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human PKN1 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652947(CHEMBL5687057)
Affinity DataIC50: 4nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human PKN1 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652950(CHEMBL5687053)
Affinity DataIC50: 5nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  5.30nMAssay Description:Binding affinity to PKN1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50308060(CEP-701 | 16-hydroxy-16-(hydroxymethyl)-15-methyl-...)
Affinity DataKd:  5.30nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)
Affinity DataKd:  6nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PKN1 (unknown origin) expressed in baculovirus infected Sf9 insect cells i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50324316(N*1*-(3-Pyridin-4-yl[2,6]naphthyridin-1-yl)ethane-...)
Affinity DataIC50: 7nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of PAK1 (unknown origin) in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50112355(CHEMBL3609326)
Affinity DataIC50: 8nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652946(CHEMBL5687023)
Affinity DataIC50: 8nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  9.30nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM31094(PKC-412 | cid_24202429)
Affinity DataKd:  9.30nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  9.30nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50326053(PKC-412 | CHEMBL608533 | US20240132489, Compound S...)
Affinity DataKd:  9.30nMAssay Description:Binding affinity to PKN1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652949(CHEMBL5687001)
Affinity DataIC50: 10nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)
Affinity DataKd:  11nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-GST-tagged PKN1 (unknown origin) expressed in baculovirus infected Sf9 insect cells i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataKi:  14nMAssay Description:Inhibition of recombinant PAK1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 14nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652952(CHEMBL5686987)
Affinity DataIC50: 20nMAssay Description:Inhibition of PAK1 (unknown origin) using 5-FAM-KPDRKKRYTVVGNPY-amide as substrate incubated for 120 mins by caliper off-chip mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM213235(FRAX414)
Affinity DataIC50: 20nMAssay Description:Inhibition of PAK1 (unknown origin) in presence of ATP by Z-LYTE enzymatic kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50148931(CHEMBL3770186)
Affinity DataKi:  23nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataKd:  34nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50391898(CHEMBL2147538)
Affinity DataIC50: 35nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50326054(CHEMBL1240703)
Affinity DataKd:  57nMAssay Description:Binding affinity to PKN1More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50596594(CHEMBL5182936)
Affinity DataKi:  60nMAssay Description:Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assay dependent Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50652944(CHEMBL3596912)
Affinity DataIC50: 64nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataKi:  81nMAssay Description:Inhibition of human PRK1 assessed as inhibition constant in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM101618(US8530652, 114)
Affinity DataIC50: 82nMAssay Description:Inhibition of human PRK1 in presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50028033(CHEMBL3338837 | US11458138, Example 312)
Affinity DataIC50: 99nMAssay Description:Inhibition of PKN-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM27400(1-ethyl-2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)
Affinity DataKi:  108nMAssay Description:Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assay dependent Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50596594(CHEMBL5182936)
Affinity DataIC50: 120nMAssay Description:Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM27344(JMC502647 Compound 8 | 2-(pyridin-4-yl)-1H,4H,5H,6...)
Affinity DataKi:  150nMAssay Description:Inhibition of PKN1 (unknown origin) by TR-FRET-based tracer displacement assay dependent Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd:  170nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  180nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2011
Entry Details
PCBioAssay
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  180nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM25118(4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-...)
Affinity DataKd:  180nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase N1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50193995(CP-690550 | 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrro...)
Affinity DataKd:  200nMAssay Description:Binding affinity to PKN1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
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