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Report error Found 154 Enz. Inhib. hit(s) with Target = 'Receptor tyrosine-protein kinase erbB-3'
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4552(CHEMBL288441 | SKI-606 | 4-[(2,4-Dichloro-5-methox...)
Affinity DataKd:  0.770nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50210162(CHEMBL3883534)
Affinity DataIC50: 1nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50461172(CHEMBL4228518)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50461178(CHEMBL4225777)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50461174(CHEMBL4226676)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50450868(CHEMBL4216679)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50112173(CHEMBL3608429)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50461179(CHEMBL4226151)
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50029668(AZD-9291 | Osimertinib | US10085983, Compound AZD-...)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50461175(CHEMBL4225565)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50461176(CHEMBL4227084)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50450870(Mavelertinib | PF-06747775)
Affinity DataIC50: 4nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50437353(CHEMBL2408045)
Affinity DataIC50: 4nMAssay Description:Inhibition of human HER3 expressed in baculovirus/Sf21 system by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50461177(CHEMBL4225951)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50461180(CHEMBL4225306)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50461173(CHEMBL4226937)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) using poly (Glu, Tyr) as substrate after 40 mins by kinase-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50161957(CHEMBL180022 | N-(4-(3-chloro-4-(pyridin-2-ylmetho...)
Affinity DataKd:  7.70nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50112176(CHEMBL3608432)
Affinity DataIC50: 9nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50182685(Canertinib dihydrochloride | CI-1033 | N-[4-(3-Chl...)
Affinity DataIC50: 14nMAssay Description:Inhibition of erbB3 in human MDA-MB-453 cells assessed as reduction in heregulin-stimulated tyrosine phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467144(CHEMBL4288300)
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM13216(N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyeth...)
Affinity DataKd:  18nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467162(CHEMBL4282460)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50159360(CHEMBL3786098)
Affinity DataIC50: 21nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50611358(CHEMBL5285282)
Affinity DataIC50: 23nMAssay Description:Inhibition of HER3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467143(CHEMBL4283970)
Affinity DataIC50: 27nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467148(CHEMBL4294156)
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50450867(CHEMBL4206501)
Affinity DataIC50: 36nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM149404(US8975249, I-4 | CO-1686 | Rociletinib | AVL-301 |...)
Affinity DataIC50: 46nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells preincubated for 2 hrs followed by EGF stimulation for 10 mins by sandwich ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50618990(CHEMBL5399200)
Affinity DataIC50: 49nMAssay Description:Induction of N-terminal 6xHis-tagged GST-fused human Her3 degradation expressed in baculovirus infected insect cells measured after 3 hrs by FRET ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50611359(CHEMBL5282275)
Affinity DataIC50: 49nMAssay Description:Inhibition of HER3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467152(CHEMBL4283823)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467163(CHEMBL4290750)
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467146(CHEMBL1379917)
Affinity DataIC50: 96nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM36409(CID24905147 | 2-(4-amino-1-isopropyl-1H-pyrazolo[3...)
Affinity DataKd:  120nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM6568(PD-173955 | CHEMBL386051 | 6-(2,6-dichlorophenyl)-...)
Affinity DataKd:  140nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM21(VANDETANIB | N-(4-bromo-2-fluorophenyl)-6-methoxy-...)
Affinity DataKd:  160nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467147(CHEMBL4283097)
Affinity DataIC50: 167nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467151(CHEMBL4293690)
Affinity DataIC50: 167nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50331096(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxy-7...)
Affinity DataKd:  180nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467161(CHEMBL4278997)
Affinity DataIC50: 183nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4779(cid_156414 | PD0183805 | CHEMBL545315 | CHEMBL3196...)
Affinity DataKd:  210nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467158(CHEMBL4280395)
Affinity DataIC50: 230nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467159(CHEMBL4288262)
Affinity DataIC50: 236nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM373712(US10246444, Example 92)
Affinity DataKd:  380nMAssay Description:Inhibition of recombinant human wild type partial length HER3 (684 to 987 residues) expressed in mammalian expression system by competitive binding a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467155(CHEMBL4276965)
Affinity DataIC50: 619nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5447(ZD1839 | N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[...)
Affinity DataKd:  790nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467149(CHEMBL4287629)
Affinity DataIC50: 825nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding constant for ERBB3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM50467142(CHEMBL4293134)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R mutant cytoplasmic domain expressed in baculovirus expression system using FAM-labeled peptide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
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