Compile Data Set for Download or QSAR
Report error Found 127 Enz. Inhib. hit(s) with Target = 'RAF proto-oncogene serine/threonine-protein kinase [Y340D,Y341D]'
LigandPNGBDBM210020(US9273046, 2.26 | US9895376, Compound 2.26 | US105...)
Affinity DataIC50: 0.25nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210021(US9273046, 2.27 | US9895376, Compound 2.27 | US105...)
Affinity DataIC50: 0.25nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210051(US9273046, 2.29 | US9895376, Compound 2.29 | US105...)
Affinity DataIC50: 0.25nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM373010(US9895376, Compound 2.30)
Affinity DataIC50: 0.25nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210037(US9273046, 2.1 | US9895376, Compound 2.1 | US10576...)
Affinity DataIC50: 0.300nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210022(US9273046, 2.31 | US9895376, Compound 2.31 | US105...)
Affinity DataIC50: 0.350nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM322528(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM210015(US9273046, 2.21 | US9895376, Compound 2.21 | US105...)
Affinity DataIC50: 0.400nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM322529(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM372977(US9895376, Compound 2.4a | US10576087, Compound 2....)
Affinity DataIC50: 0.540nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210044(US9273046, 2.4 | US9895376, Compound 2.4 | US10576...)
Affinity DataIC50: 0.560nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM210024(US9273046, 2.33 | US9895376, Compound 2.33 | US105...)
Affinity DataIC50: 0.600nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210002(US9273046, 2.8 | US9895376, Compound 2.8 | US10576...)
Affinity DataIC50: 0.710nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
Affinity DataIC50: 0.800nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM210023(US9273046, 2.32 | US9895376, Compound 2.32 | US105...)
Affinity DataIC50: 0.900nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM210016(US9273046, 2.22 | US9895376, Compound 2.22 | US105...)
Affinity DataIC50: 1nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM372967(US9895376, Compound 2.2a | US10576087, Compound 2....)
Affinity DataIC50: 1.20nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210034(US9273046, 1.1 | US9895376, Compound 1.1 | US10576...)
Affinity DataIC50: 1.40nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210038(US9273046, 2.2 | US9895376, Compound 2.2 | US10576...)
Affinity DataIC50: 1.40nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210013(US9273046, 2.19 | US9895376, Compound 2.19 | US105...)
Affinity DataIC50: 1.60nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210007(US9273046, 2.13 | US9895376, Compound 2.28 | US105...)
Affinity DataIC50: 1.70nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210001(US9273046, 2.7 | US9895376, Compound 2.7 | US10576...)
Affinity DataIC50: 2.10nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM372978(US9895376, Compound 2.4b | US10576087, Compound 2....)
Affinity DataIC50: 2.5nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM372985(US9895376, Compound 2.5b | US10576087, Compound 2....)
Affinity DataIC50: 2.5nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM622280(4-amino-N-(1-((2-fluorophenyl)amino)-6-methylisoqu...)
Affinity DataIC50: 2.60nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

LigandPNGBDBM622284(4-amino-N-(1-((3-chloro-4-fluorophenyl)amino)-6-me...)
Affinity DataIC50: 2.68nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

LigandPNGBDBM238347(US9388165, 3)
Affinity DataIC50: 2.80nMAssay Description:The compounds prepared in Examples were tested for inhibitory activities against three subtypes of RAF, i.e. RAF1 Y340D Y341D, BRAF normal type and B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
Go to US Patent

LigandPNGBDBM372973(US9895376, Compound 2.3a | US10576087, Compound 2....)
Affinity DataIC50: 3nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM622285(4-amino-N-(1-((2-fluoro-4-methoxyphenyl)amino)-6-m...)
Affinity DataIC50: 3.14nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

LigandPNGBDBM210032(US9273046, 3.7 | US9895376, Compound 3.7 | US10576...)
Affinity DataIC50: 3.20nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210005(US9273046, 2.11 | US9895376, Compound 2.11 | US105...)
Affinity DataIC50: 3.30nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM622277(4-amino-N-(1-(4-chloro-2-fluorobenzoyl)-6-methylis...)
Affinity DataIC50: 3.48nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

LigandPNGBDBM210009(US9273046, 2.15 | US9895376, Compound 2.15 | US105...)
Affinity DataIC50: 3.60nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM210010(US9273046, 2.16 | US9895376, Compound 2.16 | US105...)
Affinity DataIC50: 3.80nMAssay Description:Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM622276(4-amino-N-(6-methyl-1-(3-(trifluoromethyl)benzoyl)...)
Affinity DataIC50: 3.93nMAssay Description:Assay protocol: the inhibitory effects of the compounds of the present invention on the wild-type BRAF enzyme, mutant CRAF enzyme (RAF1 Y340D and Y34...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
Go to US Patent

LigandPNGBDBM322518(5-[3-(1H-benzimidazol-2-yl)chroman-6-yl]oxy-3,4-di...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322521(US10183939, Example 3 | US10183939, Example 3B | U...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322525(5-[3[4-(4-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]o...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322527(5-[3-(4-tert-butyl-1H-imidazol-2-yl)chroman-6-yl]o...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322528(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322529(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322530(5-[3-[5-(2-chlorophenyl)-1H-imidazol-2-yl]chroman-...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322531(5-[3-[5-(3-chlorophenyl)-1H-imidazol-2-yl]chroman-...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322532(5-[3-[4-(benzofuran-3-yl)-1H-imidazol-2-yl]chroman...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322533(5-[3-[5-(3-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

LigandPNGBDBM322535(5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]chroman-...)
In Depth
Date in BDB:
5/16/2019
Entry Details
Go to US Patent

Displayed 1 to 50 (of 127 total ) | Next | Last >>
Jump to: